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Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Gralise (gabapentin) and Cymbalta (duloxetine) are used to treat different types of neuralgia (nerve pain). Gabapentin is used postherpetic neuralgia from herpes zoster (nerve damage from shingles) and to treat seizure disorders. Is duloxetine the same as gabapentin? No, duloxetine and gabapentin are not the same medication and have different mechanisms of action and uses. Duloxetine is a medication used to treat depression, anxiety disorders, and chronic pain. Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, and central sensitization. [10] [11] It is taken by mouth. [10] Duloxetine is a serotonin–norepinephrine reuptake inhibitor Although both gabapentin and duloxetine can treat chronic pain, particularly neuropathic pain, they come from distinct classes, possess different mechanisms, and treat a variety of conditions beyond just nerve issues. Understanding these differences is crucial for selecting the appropriate therapy. Compare common side effects, interactions, warnings, and more. Cymbalta ® (duloxetine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat depression and anxiety by increasing the available levels of serotonin and norepinephrine in the brain, which helps improve mood and relieve pain. I am taking 300mg of Gabapentin twice a day and my neurologist seems to feel pretty strongly that I add 30mg of Cymbalta. Does anyone else take this combo? I really hate adding new medications! Interested in more discussions like this? Go to the Neuropathy Support Group. @jeanniem Hello, Jeanniem. For most individuals, it is safe to take gabapentin and Cymbalta (duloxetine) together. In fact, they are commonly used in combination to treat certain conditions, like neuropathy (nerve-type pain). There are some precautions, that I list below, but generally, they are of low risk. Yes, Gabapentin and Duloxetine have no reason to be taken together, so there are no issues if they were to be taken together. Still, Gabapentin and Duloxetine both have side effects that can make you tired and sleepy, so if an individual accepts them together, they must be aware of the adverse side effects. Duloxetine has antidepressant, anti-anxiety, and pain-relieving properties; however, it may cause a discontinuation syndrome on withdrawal even when tapered. Symptoms may include anxiety, headache more. Gabapentin is an anticonvulsant with pain-relieving effects that may be used to treat certain seizure disorders or relieve nerve pain. The following applies to the ingredients: Gabapentin and Duloxetine (found in Cymbalta) Treatment with DULoxetine may occasionally cause blood sodium levels to get too low, a condition known as hyponatremia, and using it with some anticonvulsants can increase that risk. Duloxetine and gabapentin are both anticonvulsants that can cause hyponatremia and seizures. They may also interact with alcohol and affect your nervous system, liver, and judgment. An interaction with duloxetine could cause a serious condition called serotonin syndrome. Duloxetine is not approved for use by anyone younger than 7 years old. To make sure duloxetine is safe for you, tell your doctor if you have: heart problems, high blood pressure; liver or kidney disease; slow digestion; a seizure; bleeding problems; sexual Comparing Cymbalta vs Gabapentin. View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Cymbalta (duloxetine) Both duloxetine and gabapentin are used to treat certain types of nerve pain. If you have questions about how duloxetine, fluoxetine, venlafaxine, and gabapentin are alike and different, talk with I'm taking 160 mgs duloxetine and 2400 mgs of gabapentin daily. So far I haven't had problems. The duloxetine is for severe depression caused by chronic pain and the gabapentin is for restless leg syndrome and nerve pain. Serious side effects of duloxetine. Along with its needed effects, duloxetine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking duloxetine: Incidence not known Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings When duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, fibromyalgia, or ongoing bone or muscle pain, it is usually taken once a day with or without food. Take duloxetine at around the same time(s) every day. Applies to: gabapentin and Cymbalta (duloxetine) Treatment with DULoxetine may occasionally cause blood sodium levels to get too low, a condition known as hyponatremia, and using it with some anticonvulsants can increase that risk.
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