Research suggests that women who take gabapentin during pregnancy may have a higher likelihood of giving birth to babies with malformations, such as cleft lip, cleft palate, and heart defects. Applies to gabapentin: oral capsule, oral solution, oral suspension, oral tablet, oral tablet extended release 24 hr. Serious side effects of gabapentin. Along with its needed effects, gabapentin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. There's no evidence to suggest that taking gabapentin reduces fertility in either men or women. However, discuss your pregnancy plans with a doctor. They may wish to review your medicine and prescribe a higher dose of folic acid for you to take (5mg a day) before you become pregnant. are pregnant or plan to become pregnant. are breastfeeding or plan to breastfeed. Gabapentin side effects. Gabapentin is approved by the FDA because it is safe and effective for the majority of people who take it. However, there are risks associated with all medicines. Some side effects caused by gabapentin can be very serious, and even life The safety of the use of gabapentin in pregnant women has always been a serious issue, as gabapentin can cross placental barriers. The impact of gabapentin on brain development in the fetus is not sufficiently investigated, which poses difficulties in clinical decisions regarding prescriptions. Gabapentin side effects can also include an increased risk of suicidal thoughts and behaviors (the Food and Drug Administration issued a warning about this possible in 2008). Talk to a doctor or a It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take gabapentin. Advice and warnings for the use of Gabapentin during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out Most recently, a prospective study from researchers at the Motherisk program reports on the outcomes of 223 pregnancies exposed to gabapentin and 223 unexposed pregnancies. In this study, the rates of major malformations were similar in the two groups. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. In this large population-based study, we did not find evidence for an association between gabapentin exposure during early pregnancy and major malformations overall, although there was some evidence of a higher risk of cardiac malformations. Maternal use of gabapentin, particularly late in pregnancy This is a very small sample size and insufficient to draw any definitive conclusions about how gabapentin affects pregnant women and the fetus. Other studies show that the connection between gabapentin and adverse birth outcomes is mostly inconclusive. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. Stopping gabapentin suddenly can cause serious problems. Gabapentin can cause serious side effects including: 1. Suicidal Thoughts. Like other antiepileptic drugs, gabapentin may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. In our study, only 28% of the women continued taking gabapentin throughout pregnancy as two-thirds of the women (66%) discontinued in the first trimester, most following pregnancy confirmation between 6 and 8 weeks’ gestation. The way a medicine impacts a pregnancy depends on the medicine itself. There are several ways medicines can affect the fetus, including: No effect. Many medicines don't have any impact on pregnancy. Direct impact. Some medicines affect the fetus directly, causing damage, birth defects or death. Indirect impact. Some medicines indirectly affect Importantly, most medicines will not affect the results of a home pregnancy test. Alcohol and illicit drugs also don’t affect pregnancy test results. Other factors that can cause inaccurate results on pregnancy tests may include: Incorrect use of the test; Testing too early; Use of an expired test; Certain cancers; Early miscarriage Pregnant women and their physicians should weigh the benefits of treatment with gabapentin with the risks of potential adverse pregnancy outcomes associated with its use. Gabapentin is a gamma-aminobutyric acid (GABA) analog with GABA agonist activity. To provide information regarding the effects of in utero exposure to gabapentin, physicians are advised to recommend that pregnant patients taking gabapentin enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. How Gabapentin Can Be Addictive Background: Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes.
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