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More rarely, gabapentin can cause fluid buildup (edema), weight gain, and vision problems. It can also cause diarrhea. More serious (but rare) side effects include suicidal thoughts or behavior, and mood changes in children. It's always good to review the potential benefits and harms of these medications with your doctor. If a drug appears problematic, the two of you can explore alternatives by considering the reason it was prescribed and seeing if there is a different type of drug that can be used as a replacement. Don't stop taking the drugs on your own. Stopping gabapentin suddenly can cause serious problems, like withdrawal symptoms or the return of seizures. Your doctor will help you stop taking the drug safely. Drug interactions While it is not FDA-approved for treating sleep disorders other than RLS, Gabapentin is occasionally used off-label to address sleep-related issues. The impact of Gabapentin on sleep quality varies from person to person, but here are the common ways in which Gabapentin can influence sleep: 1. There are postmarketing reports of withdrawal symptoms shortly after discontinuing this drug. The most frequently reported reactions with abrupt discontinuation have included anxiety, insomnia, nausea, pain, and sweating. Discontinuation at higher than recommended doses have been associated with agitation, disorientation and confusion. Can gabapentin help you sleep? Yes, it can. As reported in a small study that was published in the March-April 2010 edition of the journal Clinical Neuropharmacology, “Gabapentin enhances slow-wave sleep in patients with primary insomnia. Potential Benefits of Gabapentin for Sleep Disorders. Despite the uncertainties surrounding its impact on REM sleep, gabapentin has shown promise in treating various sleep disorders. Its use in managing insomnia, particularly in patients with chronic pain or anxiety, has garnered attention from sleep specialists. Can Gabapentin Cause Sleep Problems? Gabapentin is not only prescribed for insomnia. For instance, your doctor might give you gabapentin if you’re suffering from a variety of non-sleep-related medical conditions, such as postherpetic neuralgia. Taking gabapentin or pregabalin with opioids, anxiety meds or antidepressants, or if you have lung issues or are elderly, can lead to serious breathing problems. Watch for breathing issues Some studies have found that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical restoration and cognitive function. Additionally, it may reduce sleep fragmentation, leading to fewer nighttime awakenings and improved sleep continuity. Like baclofen, some studies have shown that gabapentin might be of interest in alcohol dependence management [2]. In this context, baclofen is linked to sleep apnea syndrome [3, 4], aggravating sleep-disordered breathing by depressing central ventilatory drive and/or increasing upper airway obstruction. Most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. Two small studies showed that gabapentin may help people with primary insomnia and occasional sleep disturbance improve total sleep time and wakefulness in the morning. Preliminary evidence indicates that gabapentin can attenuate insomnia, bolster sleep quality, and increase total sleep duration. Moreover, gabapentin has been shown to increase slow-wave sleep (SWS), promote sleep maintenance, and decrease unwanted awakenings throughout the night. Yes, gabapentin can cause insomnia as a potential side effect. What are the symptoms of insomnia? The symptoms of insomnia can include difficulty falling asleep, waking up frequently during the night, feeling tired or irritable during the day, and difficulty concentrating or remembering things. However, gabapentin can also alter REM sleep patterns, with some research indicating a reduction in REM sleep duration. The impact of Gabapentin and REM Sleep: Effects, Benefits, and Potential Risks is an area of ongoing investigation, as changes in REM sleep can affect various aspects of cognitive function and emotional processing. Some research shows gabapentin may be effective for sleep. But it comes with risks, including dizziness, falls, and fluid buildup. Gabapentin is a controlled substance in some states. It can lead to dependence and misuse. It’s best to avoid taking gabapentin with other medications that cause drowsiness, like opioids and benzodiazepines. Learn about the common side effects of gabapentin in elderly patients, including dizziness, fatigue, cognitive impairment, and more. Explore the connection between gabapentin and depression, mechanisms behind gabapentin-related depression, and strategies to manage and mitigate side effects. Discover other significant concerns for elderly gabapentin users and the importance of personalized Like baclofen, some studies have shown that gabapentin might be of interest in alcohol dependence management [2]. In this context, baclofen is linked to sleep apnea syndrome [3, 4], aggravating sleep-disordered breathing by depressing central ventilatory drive and/or increasing upper airway obstruction. Another extended-release form of gabapentin is FDA-approved to treat restless legs syndrome. This condition causes unpleasant or uncomfortable sensations in the legs and an irresistible urge to move them around, especially at night, which disrupts sleep. Doctors often prescribe gabapentin off-label to treat conditions such as: alcohol addiction.
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