I take 600 mg of gabapentin, 300 mg twice daily. No swelling in my feet. I still get some cramping and stabbing. I hope everything is going well with others. Gabapentin can cause some rare but serious side effects. While these are uncommon, people should be aware of them and seek medical attention if needed. Consult a doctor right away if you Amlodipine (Norvasc), gabapentin (Neurontin, Horizant, Gralise), and pregabalin (Lyrica) can cause puffy legs and ankles. Birth control pills, certain over-the-counter pain medications, and steroids are a few other culprits. Sorry to say, but my swelling lead to weight gain.I was prescribed Gabapentin for nerve pain. I started at 200 mgs once daily at bedtime. I couldn't stay on it for longer than two weeks. Gabapebtin can cause fluid retention which can lead to serious complications such as hyponatremia. Being that Gabapentin is an anti-convulsant, stopping it cold turkey may result in seizures- Even if you are taking it for other reasons. The best thing to do is to discuss an alternative medication with your doctor and have them ween you off. This edema is most common in your feet and ankles because gravity pulls the fluid down to your lower legs. Because of gravity, you may see more swelling after sitting or standing, but the swelling will go down if you put your legs up. There are many causes of peripheral edema, including heart failure, weak veins in your legs, or problems with Elevate your legs: If you experience swelling in the legs or feet, elevating them while sitting or lying down can help alleviate edema. Prop them up on a cushion or pillow to encourage fluid drainage. I have swelling in my legs caused by lymphedema and have to wear compression socks but mine was not caused by a medication. I also would be concerned if it's been over 5 months since stopping gabapentin and the swelling and pain is still in the hands and feet. Although gabapentin is generally well tolerated, 1 potential reported adverse effect is peripheral edema. However, due to the extensive number of etiologies of peripheral edema, medication causes may be overlooked on an inpatient psychiatric unit. Swelling in the feet and ankles. Patients taking Neurontin may experience swelling in the feet and ankles. The presence of lower leg swelling may cause discomfort and impair walking. My mother-in-law was unable to wear regular shoes because of swelling of her feet and ankles, so we found her socks and soft slippers that fit her feet comfortably. My legs, feet, hands were all holding fluid! Do you get a leaflet with your medication from your pharmacy? In Ontario I get a leaflet of all of the side effects and benefits. swelling is definately listed, as is blurry vision, mood swings, depression, headache., etc. I had most of them but it got better as time went on. Swelling never got So if you experience symptoms of edema, such as unusual swelling, let your prescriber know. And if you experience painful swelling that’s warm to the touch or red, this may be a sign that you have a blood clot. Blood clots aren’t caused by gabapentin and can be serious. Seek medical attention right away if you experience this. 4. Weight gain Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Related studies Foot, leg, and ankle swelling in Gabapentin; How the study uses the data? The study is based on gabapentin (the active ingredients of Gabapentin). Other drugs that have the same active ingredients (e.g Along with its needed effects, gabapentin (the active ingredient contained in Neurontin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking gabapentin: More common side effects Yes, gabapentin may cause fluid retention and induce edema in arms and legs. Experts believe that this side effect can also be the reason for weight gain by increasing your water weight. It can also make the body look bulky. What does research suggest? A case study included a 46 year old male whose health started deteriorating. Gabapentin can cause changes in kidney function or fluid balance in the body. When the body retains excess fluid, it can lead to noticeable swelling in areas like the legs, ankles, or hands. In rare cases, swelling may result from an allergic reaction to gabapentin. Although the mechanism behind peripheral edema from gabapentin is largely unknown, it has been theorized to be similar to the mechanism in which other calcium channel blockers (eg, amlodipine) cause peripheral edema. 6,7 This relationship has been hypothesized to be due to gabapentin's actions on presynaptic voltage-gated calcium channels. 1,6 This case illustrates that lower doses of gabapentin can also cause this adverse effect. It is important to recognize this adverse effect because gabapentin is used in conditions like diabetic neuropathy, which is associated with multiple co-morbidities that can give rise to bilateral leg swelling. Presence of gabapentin induced leg swelling In short, gabapentin can both alleviate certain types of leg discomfort and also contribute to a range of problems, including swelling, weakness, and even an increased risk of blood clots in the legs. The impact is multifaceted, varying greatly between individuals and dependent on factors like dosage, pre-existing conditions, and age.
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