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The authors suggested that there is probably an active transplacental transport of gabapentin, with accumulation in the fetus, which could be by the specific l-type amino acid transporter and is expressed in the placenta. The newborns appeared to have a slightly lower capacity to eliminate gabapentin than do adults. What does gabapentin do to a fetus? Despite the large attenuations from crude to adjusted results, maternal use of gabapentin late in pregnancy, regardless of its use early in pregnancy, remained associated with an approximately 20% to 30% increased risk of preterm birth and a 30% to 40% increased risk of SGA. Can gabapentin harm a fetus? It is not known if gabapentin tablets can harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking gabapentin tablets. You and your healthcare provider will decide if you should take gabapentin tablets while you are pregnant. Maternal use of gabapentin, particularly late in pregnancy, was associated with a higher risk of PTB, SGA, and NICUa. The study supports the reproductive safety of gabapentin during pregnancy. The U.S. Food and Drug Administration classifies gabapentin (Neurontin) as a Pregnancy Category C medication, which means that animal studies conducted on this medication has caused harm on the fetus. It is not known if gabapentin can harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking gabapentin. You and your healthcare provider will decide if you should take gabapentin while you are pregnant. It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take gabapentin. Gabapentin is an anti-seizure drug and some of these can affect folic acid levels. Women taking gabapentin while trying to conceive and during pregnancy should therefore be prescribed a high dose folic acid supplement (5mg/day). There's no evidence to suggest that taking gabapentin reduces fertility in either men or women. However, discuss your pregnancy plans with a doctor. They may wish to review your medicine and prescribe a higher dose of folic acid for you to take (5mg a day) before you become pregnant. Pregabalin and gabapentin cross the placenta barrier using active transport mechanisms [1], [2], raising concerns about potential adverse effects on the fetus and infants when these medications are used during pregnancy. In addition, this review only profiled the drugs that can affect spermatogenesis. This is a limitation of the study, because drug-induced male infertility can affect a wide variety of processes and steps, from spermatogenesis to the successful birth of a term fetus. The information provided here only refers to the first step. Our results add to the current understanding of the safety of gabapentin prenatal use and provide pregnant women with pain conditions and epilepsy and their providers with important information, which can guide clinical decisions during pregnancy. You can find information about the risks of individual medicines below. You can then discuss this information with your epilepsy specialist or epilepsy specialist nurse (ESN). There are extra rules for prescribing sodium valproate and topiramate. These medicines have higher risks. We have more information on our sodium valproate and topiramate -The risk of having a child with a congenital defect as a result of antiepileptic medication is far outweighed by the dangers to the mother and fetus of uncontrolled epilepsy; folic acid supplementation (5 mg) should be started 4 weeks prior to and continued for 12 weeks after conception. It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among people who take gabapentin. There was an increased risk of preterm birth among women exposed to gabapentin either late (RR=1.28 [CI 1.08-1.52], p < 0.01) or both early and late in pregnancy (RR=1.22 [1.09-1.36], p < 0.001). Gabapentin is an anti-seizure drug and some of these can affect folic acid levels. Women taking gabapentin while trying to conceive and during pregnancy should therefore be prescribed a high dose folic acid supplement (5mg/day). Gabapentin is a potent anticonvulsant medication, and most studies show that it should not harm a developing fetus. There may be a possible correlation between gabapentin use and preterm births, but more studies are needed to determine the correlation. Before taking gabapentin, tell your healthcare provider if you: have or have had kidney problems or are on hemodialysis have or have had depression, mood problems, or suicidal thoughts or behavior are pregnant or plan to become pregnant. It is not known if gabapentin can harm your unborn baby.
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