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Examining individual trials, the two trials that evaluated 900 mg/d of gabapentin reported that hot flashes were decreased by 45% to 50% (Fig 1E). 15,16 In the individual patient trial that studied 2,400 mg/d, hot flashes were reported to be reduced by approximately 80% (Fig 1E). 17 In this last trial, however, there was a much more substantial A multifactorial approach is recommended. Advice to patients should include keeping a diary of hot flashes to look for “triggers.” Regular exercise helps to reduce hot flashes, 34 as does avoiding spicy foods and alcohol. Wearing layered clothing can help because layers can be removed or added easily. Keywords: hot flashes, men, prostate cancer, gabapentin. Background. Hot flashes are a problematic issue for many men diagnosed with prostate cancer, affecting up to 75% of those on medical or surgical androgen deprivation therapy 1,2. Several clinical studies have shown that gabapentin becomes effective at reducing hot flashes within around 4 weeks of taking it consistently. And while some may feel a benefit Fortunately, a new treatment option may be able to treat hot flashes without the risk. Gabapentin, an anticonvulsant, may be effective for the treatment of hot flashes. Often sold as Neurontin, gabapentin is approved by the Food and Drug Administration (FDA) for the treatment of epilepsy. earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and The following search terms were used: "menopause," "hot flushes," "vasomotor symptoms," "gabapentin," and "non-hormonal therapy." Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and dropout rate. Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. Gabapentin presents a promising option for managing hot flashes, particularly for those who haven’t found relief through other treatments. By understanding its benefits, potential side effects, and proper administration, you can make informed decisions about its use. This review investigated the efficacy and tolerability of gabapentin for the treatment of hot flashes in menopausal women. Gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women, but there was substantial variation in the results across the included trials. The authors' conclusions appear to be reliable based on the evidence presented. A 2005 study by Pandya et al. randomized 420 women with breast cancer and experiencing at least 2 hot flashes in 24 hours to one of three groups: gabapentin 300 mg daily, gabapentin 900 mg daily, or placebo 23. After 8 weeks, the 300 mg dose group showed a modest 20% reduction in hot flashes, but the 900 mg dose group showed a reduction of Randomised placebo-controlled trials have shown that venlafaxine, 16 fluoxetine, 17 and paroxetine 18 are effective in control of hot flashes. Gabapentin is a GABA analogue used in the treatment of epilepsy, neurogenic pain, restless-leg syndrome, essential tremor, bipolar disorder, and migraine prophylaxis; it was first reported for its The use of gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women by 20% to 30%, but the high level of heterogeneity across the studies precluded the provision of a reliable summary effect. Although a double-blind placebo-controlled clinical trial should be conducted to better elucidate the efficacy and toxicity of gabapentin in patients with hot flashes, the available data suggest that gabapentin is a reasonable treatment to consider in patients with hot flashes if they do not wish to use hormonal therapy. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep Reviews and ratings for Gabapentin when used in the treatment of hot flashes. 122 reviews submitted with a 8.7 average score.
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