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The results revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all subgroups except for the strata having depression or head injury. The risk of dementia development was higher in the younger group (age <50 years) than that in the older group. The evidence of gabapentin and dementia is mixed, with two studies looking at hundreds of thousands of people and coming to completely different conclusions. We would like to show you a description here but the site won’t allow us. Since gabapentin is also prescribed to treat behavioral and psychological symptoms of dementia (BPSD) 19, gabapentin could be widely prescribed in patients with dementia. However, a recent paper addressed that there is a possibility of an association between gabapentin and cognitive decline 20. Older adults who take gabapentin also are at higher risk of breathing problems. Because gabapentin can enhance the psychological effect of opioids, it has the potential to be abused and has contributed to drug overdose deaths. Drugs such as gabapentin have been linked in rare cases to an increased risk of suicidal thoughts or behaviors. Evidence in frontotemporal dementia is lacking. Conclusion. Gabapentin and pregabalin could be considered for BPSD when medications having stronger evidence bases (risperidone, other antipsychotics, carbamazepine and citalopram) have been ineffective or present unacceptable risks of adverse outcomes. Doctors often prescribe gabapentin to prevent epilepsy-related seizures and nerve pain. It is generally safe but can have side effects, including blurred vision and behavior changes. And since treatment options for dementia are limited, prevention is key. Dementia risk is tied to common things like diabetes, high blood pressure, and physical inactivity. But some common medications are associated with dementia risk, too. Here are four common drug classes linked to dementia, and what the research says about your risk. 1. Two common classes of drugs have been linked to dementia. Fortunately, there are alternatives to both. If you're worried about developing dementia, you've probably memorized the list of things you should do to minimize your risk—eating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. For many of the same reasons they can make symptoms of dementia worse, certain medications may increase the risk of developing dementia over all. Anticholinergic medications, in particular, have Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. Two new studies highlight a significant increase in harmful side effects related to the use of commonly prescribed opioid painkillers in people with dementia. Researchers also identified a This is true for all gabapentin products, which can cause withdrawal symptoms like anxiety, agitation, and nausea or vomiting. More seriously, stopping treatment with gabapentin abruptly can lead to seizures. If you want to stop taking gabapentin, don’t make any changes without talking to your prescriber. Maust says that providers and caregivers have the right motivation for trying to address dementia-related behaviors through medication: to reduce distress in the patients, and sometimes also in the caregivers. Often the long-term goal is to make it possible for the person with dementia to avoid having to move to a long-term care facility. Over 1 or 2 years of follow-up, gabapentin initiation was not associated with decline in cognitive or functional status but was associated with increased odds of falling among research participants with cognitive impairment. Gabapentin use was significantly associated with decline in cognitive and functional status among older adults with initially normal cognition. Further studies are needed to examine the association. However, several case reports in which gabapentin was used for agitation in dementia with Lewy bodies question its appropriateness for all types of dementia-related agitation [14–16]. Indeed, paradoxical gabapentin-induced exacerbation of psychosis in a patient with schizophrenia has already been described [ 17 ]. This causes dementia symptoms to worsen or even to start showing up in seniors without dementia. Anticholinergic drugs can increase dementia risk by 54%. Seniors who don’t have Alzheimer’s or dementia still need to be careful of anticholinergic medications. That’s because these drugs can increase the risk of developing dementia in the future. The study showed that gabapentin use not linked to higher dementia risk. No elevated dementia risk was found across varying dosage levels or among different age and gender subgroups.
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