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Are there any risks of taking gabapentin during pregnancy? Gabapentin use in pregnancy is not very well-studied. While the available information does not strongly suggest that it causes problems for the baby, further research is required to prove that gabapentin is safe. There is evidence to suggest that gabapentin use during pregnancy may be associated with an increased risk of certain birth defects. These can range from mild, such as cleft lip or palate, to more severe, such as heart defects or neural tube defects. The researchers reported 2 major malformations in infants exposed to gabapentin in the first trimester of pregnancy. 3 In another group of 7 women with hyperemesis gravidarum, 2 congenital defects were reported. 4 A cohort study in Denmark reported on 59 fetuses exposed to gabapentin during pregnancy, and documented 1 major malformation and 6 Ms. P is a 32-year-old married woman who presented for consultation regarding the use of medication during pregnancy. She had been taking fluoxetine (Prozac) 20 mg for many years for the treatment of recurrent major depression and generalized anxiety. In addition, she was prescribed gabapentin (Neurontin) for sleep. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. Some seizures can stress the body so much that it may lead to a miscarriage. Taking gabapentin is overall safer than having seizures while pregnant. Should You Take Gabapentin While Pregnant? Gabapentin is a potent anticonvulsant medication, and most studies show that it should not harm a developing fetus. Our study population, which included 4,642 pregnancies exposed to gabapentin during T1 and was not limited to women with epilepsy, allowed us to rule out meaningful increases in the risk of overall major malformations among pregnancies exposed to gabapentin during T1 with higher precision, while permitting to identify a potential moderate While gabapentin (Neurontin) is now used in a wide variety of clinical settings — for epilepsy, pain management, restless leg syndrome, anxiety, and sleep disturbance – there is relatively little information regarding its reproductive safety. More research is required to define the pregnancy safety profile of gabapentin. Pregnant women and women of childbearing potential should be made aware of the lack of data for most pregnancy outcomes. Gabapentin should only be used during pregnancy where benefits of treatment are considered to outweigh any potential risks. While regional anesthesia is in general considered safe during pregnancy, the minimum effective dose should be used. Key Take Aways The use of non-pharmacological pain management interventions (exercise, acupuncture, behavioral and relaxation exercises among others) should be emphasized in the treatment of pain in pregnant patients. If you have an unplanned pregnancy while taking a medicine, you should tell your doctor as soon as possible. If a new medicine is suggested for you during pregnancy, please make sure that the person prescribing it knows that you are pregnant. If you have any concerns about a medicine, you can check with your doctor, midwife or pharmacist. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. Due to mixed findings on its safety during pregnancy, gabapentin shouldn’t be taken during pregnancy without first discussing it with your doctor. Gabapentin (Neurontin) is an anti-seizure medication that’s also used for certain types of neuropathic pain. There's no evidence to suggest that taking gabapentin reduces fertility in either men or women. However, discuss your pregnancy plans with a doctor. They may wish to review your medicine and prescribe a higher dose of folic acid for you to take (5mg a day) before you become pregnant. any changes to how you take your medication. Your healthcare providers can talk with you about the benefits of treating your condition and the risks of untreated illness during pregnancy. I take gabapentin. Can it make it harder for me to get pregnant? It is not known if gabapentin can make it harder to get pregnant. Advice and warnings for the use of Gabapentin during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out any changes to how you take your medication. Your healthcare providers can talk with you about the benefits of treating your condition and the risks of untreated illness during pregnancy. I take gabapentin. Can it make it harder for me to get pregnant? It is not known if gabapentin can make it harder to get pregnant. Maternal use of gabapentin, particularly late in pregnancy, was associated with a higher risk of PTB, SGA, and NICUa. Prenatal exposure to pregabalin is associated with an increased risk of congenital anomalies and long-term neurodevelopmental outcomes while gabapentin exposure was associated with an increased risk of preeclampsia, preterm birth and small-for-gestational age. Larger studies are needed to confirm these data and explore additional outcomes.
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