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Researchers compare four treatments for neuropathy. Researchers publishing in JAMA Neurology describe the results of a unique trial in which 402 people with idiopathic sensory polyneuropathy were randomly assigned to one of four medications: duloxetine, mexiletine, nortriptyline, or pregabalin. After 12 weeks, each person rated their neuropathy Compare Carbamazepine vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Carbamazepine vs gabapentin: Carbamazepine is mainly used for seizures and trigeminal neuralgia, while gabapentin treats nerve pain and seizures. Gabapentin has fewer drug interactions, but carbamazepine is more effective for specific neuralgias. We would like to show you a description here but the site won’t allow us. Many medical and surgical treatments are available. Most patients respond well to pharmacotherapy; carbamazepine and oxcarbazepine are first line therapy, while lamotrigine and baclofen are considered second line treatments. Other drugs such as topiramate, levetiracetam, gabapentin, pregabalin, and botulinum toxin-A are alternative treatments. Anticonvulsants are divided into two categories: newer (e.g., gabapentin [Neurontin], pregabalin [Lyrica]) and traditional (e.g., carbamazepine [Tegretol], valproate [Depacon]). Compare risks and benefits of common medications used for Peripheral Neuropathy. Find the most popular drugs, view ratings and user reviews. Gabapentin dosing for neuropathic pain: evidence from randomized placebo‐controlled clinical trials. Clinical Therapeutics 2003;25(1):81‐104. [Google Scholar] Beydoun 2002a. Beydoun A, Schmidt D, Souza J. Oxcarbazepine versus carbamazepine in trigeminal neuralgia: a meta‐analysis of three double‐blind comparative trials. Keywords: gabapentin, carbamazepine, primary trigeminal neuralgia, randomized controlled trial, meta-analysis. Citation: Zhao X and Ge S (2023) The efficacy and safety of gabapentin vs. carbamazepine in patients with primary trigeminal neuralgia: A systematic review and meta-analysis. Front. Neurol. 14:1045640. doi: 10.3389/fneur.2023.1045640 A retrospective study reported the efficacy of gabapentin, with a mean dosage of 930 mg, in 43 out of 92 patients with TN. 10 Gabapentin was also reported as an effective option in patients with TN related to multiple sclerosis, to lower the dose of carbamazepine or lamotrigine when these drugs produce intolerable side effects. 11 The superiority of gabapentin over carbamazepine in treating the chronic nerve condition trigeminal neuralgia remains inconclusive, according to the findings in a new meta-analysis published in The first double-blind, crossover trial to evaluate the efficacy of oxcarbazepine (900–2100 mg/ day) versus carbamazepine (400–1200 mg/day) reported a comparable analgesic effect between the two treatments, leading to the conclusion that oxcarbazepine offers an alternative to carbamazepine in the treatment of TGN. 19 This finding was confirmed by the results of three subsequent multicenter Two small trials have shown carbamazepine to be beneficial in the treatment of diabetic neuropathic pain. Carbamazepine shows similar clinical effect to gabapentin (Neurontin) and phenytoin The Neuropathic Pain Special Interest Group of the International Association for the Study of Pain recently sponsored the development of evidence-based guidelines for the pharmacological treatment of neuropathic pain. Tricyclic antidepressants, dual reuptake inhibitors of serotonin and norepinephrine, calcium channel α2-δ ligands (ie, gabapentin and pregabalin), and topical lidocaine were The first double-blind, crossover trial to evaluate the efficacy of oxcarbazepine (900–2100 mg/ day) versus carbamazepine (400–1200 mg/day) reported a comparable analgesic effect between the two treatments, leading to the conclusion that oxcarbazepine offers an alternative to carbamazepine in the treatment of TGN. 19 This finding was Carbamazepine is the first choice for the treatment of primary trigeminal neuralgia, and it is effective for most patients, but it has many adverse reactions; blood routine, electrolytes, and liver and kidney functions should be monitored during medication (13). With the exception of carbamazepine for trigeminal neuralgia, there is little evidence to support the use of anticonvulsants as first-line treatment. There is evidence from randomised controlled trials that gabapentin has an effect in diabetic neuropathic pain and post-herpetic neuralgia. Gabapentin has demonstrated efficacy, specifically in painful diabetic neuropathy and postherpetic neuralgia. Lamotrigine has been reported to be effective in relieving pain from trigeminal neuralgia refractory to other treatments, HIV neuropathy, and central post-stroke pain. Results from clinical trials of phenytoin are equivocal. Both gabapentin and pregabalin are particularly effective in the treatment of postherpetic neuralgia, diabetic neuropathy and pain caused by a spinal cord injury. Pregabalin may also be used to treat fibromyalgia. Pregabalin (Lyrica), gabapentin (Neurontin), amitriptyline (except in older adults), or duloxetine (Cymbalta) should be used as first-line treatment for painful diabetic peripheral neuropathy. A 1
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