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The current evidence showed that gabapentin may be superior to carbamazepine in relation to efficacy and safety in patients with PTN. It is crucial that more RCTs are conducted to confirm the conclusion in the future. There is consensus that oxcarbazepine is an effective treatment in persons with trigeminal neuralgia and may have fewer adverse effects than carbamazepine, although there is a lack of data from Keywords: gabapentin, carbamazepine, primary trigeminal neuralgia, randomized controlled trial, meta-analysis. Citation: Zhao X and Ge S (2023) The efficacy and safety of gabapentin vs. carbamazepine in patients with primary trigeminal neuralgia: A systematic review and meta-analysis. Front. Neurol. 14:1045640. doi: 10.3389/fneur.2023.1045640 For instance, Tegretol is commonly employed as an initial choice for treating trigeminal neuralgia and certain seizure disorders whereas Gabapentin is generally considered first-line treatment for neuropathic pain or postherpetic neuralgia. Carbamazepine vs Gabapentin. Carbamazepine, with the chemical formula C15H12N2O and CAS number 298-46-4, is a widely used anticonvulsant.It is particularly effective for treating various seizure disorders and provides relief for nerve pain conditions, such as trigeminal neuralgia and diabetic neuropathy. Guidelines for the diagnosis and treatment of patients with trigeminal neuralgia (TN) advocate for a multidisciplinary team approach to improve the care of patients with acute and chronic TN. Evidence-based discussions and decisions are encouraged to establish care pathways for prompt diagnosis and treatment, and long-term outcomes data collection to improve care. The guidelines include Conclusion: The current evidence showed that gabapentin may be superior to carbamazepine in relation to ecacy and safety in patients with P TN. It is crucial that more RCTs are conducted to The superiority of gabapentin over carbamazepine in treating the chronic nerve condition trigeminal neuralgia remains inconclusive, according to the findings in a new meta-analysis published Introduction. Trigeminal neuralgia (TN) is a peculiar neuropathic facial pain condition characterized by paroxysmal pain in the distribution territory of one or more divisions of trigeminal nerve, evoked by tactile, innocuous stimulation of trigger zones. 1 Trigger zones and paroxysmal pain sensation may be dissociated, probably due to a phenomenon of cross-excitation between somatosensory To evaluate the safety and efficacy of gabapentin in comparison with carbamazepine in the treatment of trigeminal neuralgia, a meta-analysis of randomized controlled trials was performed. Two reviewers independently selected studies, assessed study quality, and extracted data. Compare Gabapentin vs Tegretol head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Prescribed for Trigeminal Neuralgia Carbamazepine: Based on clinical studies, carbamazepine is the estab-lished first-line treatment option for TGN; it is also the only FDA-approved drug with a specific indication for TGN. 10-13 The usual starting dose of carbamazepine is 100 to 200 mg twice daily, administered orally, which can be increased as tolerated to a maintenance dose of Aim: This study aimed to assess the safety and effectiveness of carbamazepine in treating trigeminal neuralgia in contrast to gabapentin. Hence, a systematic review and metaanalysis of randomised controlled trials had been carried out. Carbamazepine (Tegretol) has been studied extensively in trigeminal neuralgia, with one meta-analysis finding good evidence for its effectiveness. 15 A Cochrane review confirmed that carbamazepine high-resolution trigeminal sequences, should be performed as part of the diagnostic work- up. Carbamazepine and oxcarbazepine are drugs of first choice. Lamotrigine, gabapentin, pregabalin, botulinum toxin type A and baclofen can be used either alone or as add-on therapy. Surgery should be considered if the pain is Most patients respond well to pharmacotherapy; carbamazepine and oxcarbazepine are first line therapy, while lamotrigine and baclofen are considered second line treatments. Other drugs such as topiramate, levetiracetam, gabapentin, pregabalin, and botulinum toxin-A are alternative treatments. Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. Eur Neurol . 2000;44(1):45–48. doi: 10.1159/000008192 [ DOI ] [ PubMed ] [ Google Scholar ] Compare Carbamazepine vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Carbamazepine is the first choice for the treatment of primary trigeminal neuralgia, and it is effective for most patients, but it has many adverse reactions; blood routine, electrolytes, and liver and kidney functions should be monitored during medication (13). To evaluate the safety and efficacy of gabapentin in comparison with carbamazepine in the treatment of trigeminal neuralgia, a meta-analysis of randomized controlled trials was performed. Two reviewers independently selected studies, assessed study quality, and extracted data.
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