Gabapentin is approved to prevent and control partial seizures, relieve postherpetic neuralgia after shingles and moderate-to-severe restless legs syndrome. Learn what side effects to watch for, drugs to avoid while taking gabapentin, how to take gabapentin and other important questions and answers. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Finally, reports in general contraindicate the use of gabapentin in conditions such as myasthenia gravis and myoclonus. Contraindications : Gabapentin is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients and avoid abrupt withdrawal. Reduce dose in renal impairment. Dosing : General information about the safe and effective use of gabapentin. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use gabapentin for a condition for which it was not prescribed. Do not give gabapentin to other people, even if they have the same symptoms that you have. It may harm them. The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016). These highlights do not include all the information needed to use NEURONTIN safely and effectively. See full prescribing information for NEURONTIN. NEURONTIN ® (gabapentin) capsules, for oral use NEURONTIN ® (gabapentin) tablets, for oral use NEURONTIN ® (gabapentin) oral solution Initial U.S. Approval: 1993 General information about the safe and effective use of gabapentin. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use gabapentin for a condition for which it was not prescribed. Do not give gabapentin to other people, even if they have the same symptoms that you have. It may harm them. Generic Name Gabapentin DrugBank Accession Number DB00996 Background. Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid that was first approved for use in the United States in 1993. 16 It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures 14,5 - today it is also widely used to treat neuropathic pain. 8 Do not crush or chew sustained-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split sustained-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. These highlights do not include all the information needed to use NEURONTIN safely and effectively. See full prescribing information for NEURONTIN. NEURONTIN ® (gabapentin) capsules, for oral use NEURONTIN ® (gabapentin) tablets, for oral use NEURONTIN ® (gabapentin) oral solution Initial U.S. Approval: 1993 ----- These highlights do not include all the information needed to use NEURONTIN safely and effectively. See full prescribing information for NEURONTIN. NEURONTIN® (gabapentin) capsules, for oral use NEURONTIN® (gabapentin) tablets, for oral use NEURONTIN® (gabapentin) oral solution Initial U.S. Approval: 1993 ----- The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016). Avoid driving or hazardous activity until you know how gabapentin will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Do not stop using gabapentin suddenly, even if you feel fine. You should not take gabapentin if you are allergic to it. Gabapentin can be taken by most adults and children aged 6 and over. Gabapentin is not suitable for some people. To make sure it's safe for you, tell your doctor if you: NHS medicines information on who can take gabapentin and who may not be able to take it. When Should You NOT Give Gabapentin? A Comprehensive Guide. Contraindications: Situations Where Gabapentin Should Be Avoided; Precautions: When Gabapentin Needs Careful Consideration. Pregnancy and Breastfeeding; Kidney Problems; Respiratory Issues; Mental Health Concerns; Driving and Operating Machinery; Drug Interactions; When to Stop Taking Gabapentin is not safe for use in pregnancy but should be safe for use in lactation. Gabapentin should not be abruptly discontinued after long-term use as seizures can be precipitated. Instead, gabapentin should be gradually tapered off over a couple of weeks. Many commercially prepared gabapentin oral liquids are sweetened with xylitol, which Precautions and Contraindications. Before taking gabapentin, it is important to be aware of the following precautions and contraindications: 1. Allergy. Individuals with a known allergy or hypersensitivity to gabapentin should avoid its use. 2. Kidney problems. Gabapentin is primarily eliminated from the body through the kidneys. Screen patients for risk factors and contraindications before initiating gabapentin therapy, such as renal impairment, history of substance misuse, or concurrent medication interactions. Apply patient-centered approaches to gabapentin prescribing, tailoring dosage adjustments and treatment plans based on individual needs and preferences. The use of gabapentin tablets in patients less than 12 years of age with compromised renal function has not been studied. 2.4 Dosage in Elderly. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and dose should be adjusted based on creatinine clearance values in these patients. Point of Care - Clinical decision support for Gabapentin. Treatment and management. Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Toxicity, Enhancing Healthcare Team Outcomes
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