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Gabapentin, a commonly prescribed medication for the treatment of various conditions such as epilepsy and nerve pain, has been found to potentially affect blood sugar levels. While it is not a known side effect of gabapentin, some individuals may experience changes in their blood glucose levels while taking this medication. Although blood glucose fluctuations are a possible adverse drug reaction (ADR) of gabapentin 1, hypoglycaemia in relation to this drug was found in just one publication 3. We received six cases of (severe) hypoglycaemia in both diabetic and non-diabetic patients exposed to gabapentin, which occurred between July 2002 and July 2012. While there is evidence suggesting that gabapentin can potentially raise blood sugar levels in some individuals, particularly those with pre-existing diabetes, there are also multiple reports of gabapentin causing hypoglycemia. Summary: Blood glucose abnormal is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Metformin, and have Type 2 diabetes. Common side effects of gabapentin include: flulike symptoms such as fever or body aches. Rare but serious side effects of gabapentin include: changes in memory, ability to concentrate, or personality. Gabapentin may cause breathing problems in people who use opioid pain medicines and those with chronic obstructive pulmonary disease (COPD). A 47-year old, 68 kg, white female presented to the emergency department with altered mental status. Her blood glucose level was 33 mg/dL. Gabapentin was started 1 week prior to the hypoglycemia episode. Her past medical history, concomitant medications, and other laboratory findings were not likely causes of her severe hypoglycemia. Summary: High blood sugar is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lantus, and have Depression. Gabapentin and severe hypoglycaemia Introduction Gabapentin (Neurontin ®) is indicated for the treatment of partial epilepsy and peripheral neuropathic pain, such as diabetic neuropathy and post-herpetic neuralgia and was granted marketing authorization in the Netherlands in 1999. Gabapentin is structurally related to Hyperglycemia, or high blood sugar, can be a side effect of some common medications. Sometimes, high levels of blood sugar are temporary and settle when you stop taking the medication. But certain medications can increase the risk of developing Type 2 diabetes. Gabapentin has not been reported to raise blood sugar, however it would be best to consult a pharmacist/doc who would have prescribed the med. Take care, be well & safe! Votes: +0 amounts can raise blood sugar.) Calcipotriene + betamethasone (Enstillar®) Candesartan + hydrochlorothiazide (Atacand HCT®) Captopril + hydrochlorothiazide (Capozide®) Carfilzomib (Kyprolis®) Carteolol (Cartrol® oral, Occupress® eyedrops) Carvedilol (Coreg®) Ceftaroline (Teflaro®) Ceftozolane + tazobactam (Zerbaxa) Chlorothiazide (Diuril®) Medicines you get with a prescription and some that you buy over the counter (OTC) can be a problem for people who need to control their blood sugar. Prescription medicines that can raise Postmarketing research of gabapentin has shown fluctuation of blood glucose levels. Ask your doctor to evaluate your blood glucose levels for hypoglycemia. He/she might want to adjust your dose of gabapentin, or send you to a dietician to establish a special diet to control the low blood sugar if your glucose is not dropping too severely. Common adverse effects from gabapentin include somnolence, sedation, and dizziness. Hyperglycemia is listed as a possible adverse drug reaction in the labeling. Case reports describe hypoglycemia in patients with diabetes, peritoneal dialysis, and/or incomplete medication records. askyourpharm.com Gabapentin could be considered as a cause for otherwise unexplained hyperglycemia in a patient. Keywords: gabapentin, drugs, adverse reactions, hyperglycemia, glycemic control. The Link Between Gabapentin and Blood Sugar. The mechanism by which gabapentin might influence blood sugar levels isn’t fully understood. However, the slight increase in the risk of hyperglycemia suggests that gabapentin can, in some individuals, affect glucose metabolism. Gabapentin has been associated with both hypoglycemia and hyperglycemia in different patient cases. The drug's interaction with GABA receptors and voltage-gated calcium channels may influence insulin secretion, leading to these varying effects on blood sugar levels. Summary: Hyperglycemia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lantus, and have Depression. During hypoglycaemia, symptoms like palpitations, tremor, hunger, sweating and neuroglycopenic symptoms are accompanied by measured plasma glucose concentration below 3.9 mmol/l (70 mg/dl). In the case of severe hypoglycaemia, the event requires assistance of another person to administer carbohydrates, glucagon or resuscitative actions [2].
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