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Listed below are some drugs that may cause hyponatraemia (serum sodium concentration below 135 mmol/L) Nicotine patch therapy can induce hyponatremia. The proposed mechanism is a possible syndrome of inappropriate antidiuretic hormone (SIADH) induced by this drug. Hyponatremia is the most common electrolyte disorder and is characterized by a sodium level <135 mEq/L . It affects hospitalized patients at a greater rate than the general public. A low serum level of sodium can cause headache, fatigue, anorexia, vomiting, seizures, and coma . Yes, gabapentin can lead to hyponatremia. This is when your blood sodium levels go down. It's important to keep an eye on your sodium levels if you're taking gabapentin. CSW is a rare cause of hyponatraemia and has been reported in people with intracranial disease (for example subarachnoid haemorrhage, traumatic brain injury, or intracranial surgery). It is thought to be the result of elevated levels of atrial and/or brain natriuretic peptide, which causes an increase in sodium and water excretion . Indeed, Takei et al reported five cases of severe hyponatremia in the elderly successfully treated with low doses of hydrocortisone suggesting adrenal insufficiency as the underlying cause for the low serum sodium concentration. 99 However, replacement with hydrocortisone may require many days to restore serum sodium levels (in the cases by Carbamazepine and oxcarbazepine are the anticonvulsants most commonly reported to be associated with hyponatremia in patients with epilepsy, although other anticonvulsants, such as eslicarbazepine, sodium valproate, lamotrigine, levetiracetam, and gabapentin, have also been reported to cause hyponatremia . Moderate Interactions of Gabapentin include: aluminum hydroxide; calcium carbonate; clobazam; lurasidone; morphine; orlistat; sevelamer; sodium bicarbonate; sodium citrate/citric acid; Gabapentin has mild interactions with at least 21 different drugs. This document does not contain all possible interactions. The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Hyponatremia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Stress and anxiety. Hundreds of medications can affect your potassium level, either making it too high or too low. Drugs that can cause high potassium levels (Hyperkalemia) Some medications cause the blood level of potassium to increase, which is known as hyperkalemia. It occurs when your blood serum level exceeds 5.0 mmol/L. For older adults, low blood sodium, known as hyponatremia, can cause death if left untreated. This content does not have an English version. This content does not have an Arabic version. Carbamazepine, oxcarbazepine and sodium valproate cause an increase in production of ADH, whereas carbamazepine and lamotrigine cause potentiation of ADH effect. Oxcarbazepine has been found to Many drugs can lower your blood sodium levels or hyponatremia. Low blood sodium symptoms are associated with salt level in blood and causes of hyponatremia are decrease in sodium Expert opinion: Carbamazepine and oxcarbazepine are the most common AEDs which induce hyponatremia in patients with epilepsy. Recently, other AEDs, such as eslicarbazepine, sodium valproate, lamotrigine, levetiracetam and gabapentin have also been reported to cause hyponatremia. This study included 5027 patients receiving AED monotherapy. When we compared serum sodium levels among the AED monotherapy regimens (Table 2), there were significant differences among eight regimens (ANOVA; p < 0.001). Patients on CBZ monotherapy had a significantly lower serum sodium level than other patients. Most studies on antiepileptic drugs have been small and focused on the effect on sodium levels without addressing the clinical consequences, such as hospitalization [6], [7]. This lack of evidence can be problematic for the treating neurologist, for example when confronted with a patient with severe hyponatremia, in need of an alternative drug. More rarely, gabapentin can cause fluid buildup (edema), weight gain, and vision problems. It can also cause diarrhea. More serious (but rare) side effects include suicidal thoughts or behavior, and mood changes in children. It has been confirmed that the voltage-gated persistent sodium currents mediate the generation of subthreshold membrane potential oscillations (SMPOs) and contribute to shaping repetitive firing. Our previous study indicated that gabapentin (GBP) administration induced a dose-dependent inhibition of While taking gabapentin, certain factors may increase the risk of developing hyponatremia, a condition characterized by low levels of sodium in the blood. It is important to be aware of these factors to minimize the risk and ensure your safety.
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