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In a cross-over study comparing cognitive effects of carbamazepine vs gabapentin in healthy adults, Meador et al. found that cognitive performance while taking gabapentin was statistically better than while taking carbamazepine in 8 out of 31 neuropsychological variables; however, when compared with performance while not taking either Can Gabapentin cause memory loss? Yes, memory loss is a potential side effect of Gabapentin. While not experienced by everyone, some individuals may notice difficulties with memory or concentration while taking Gabapentin for pain and symptom management. How they can affect memory: Patients who take anticholinergics can have complications with their long-term memory, says Merrey. These medications have been associated with an increased risk of dementia, and that heightened risk can persist even after the medication has been discontinued. Dementia is one of the most prevalent neurodegenerative disorders worldwide. It causes progressive impairments in memory, executive function, learning, and ability to perform daily activities (Duong et al., 2017). Multiple factors such as genetics, lifestyle, and environment increase the risk of developing dementia. Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. The HR (95% CI) of dementia for gabapentin or pregabalin exposure was 1.45 (1.36–1.55) compared to non-exposure group, after adjustment for diabetes mellitus, hypertension, stroke, hyperlipidemia, depression, and head injury. Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). Gabapentin is an effective treatment for chronic neuropathic pain but may cause dizziness, drowsiness, and confusion in some older adults. The goal of this study was to assess the association between gabapentin dosing and adverse outcomes by This study found that not only can Gabapentin cause memory loss when abused, but it can also lead to other cognitive problems that can contribute to memory impairment. Also, Gabapentin's long-term use side effects present other dangers, such as weakened muscles, fatal toxicity, and respiratory failure. Such drugs are on the list because they share troubling side effects—confusion, clouded thinking, and memory lapses—that can lead to falls, fractures, and auto accidents. What the studies found It's important to note that neither of these studies was a randomized controlled clinical trial, so neither proved that either type of drug causes 1. Does gabapentin cause memory loss? While studies haven’t definitively confirmed gabapentin causes long-term memory loss or impairment as severe as dementia, patients can experience brain fog and slight confusion. However, it is important to acknowledge the existing evidence that links long-term gabapentin use to cognitive decline including Gabapentin use was significantly associated with decline in cognitive and functional status among older adults with initially normal cognition. Further studies are needed to examine the association. Although studies have revealed the administration of some drugs involved in GABA mechanisms of function, can damage memory by harming the neural pathways responsible for controlling cognition [27,28,29], some preclinical studies of the effect of PGB on memory, have proven otherwise [22, 27, 30,31,32,33,34,35]. While most authorities don’t suggest screening tests for dementia, there are some memory and cognitive tests that are easy to do for people who have concerns about their memory or those CDRGLOB is a ordinal rating with five levels (0: no dementia; 0.5: questionable dementia; 1: mild dementia; 2: moderate dementia; and 3: severe dementia) (Morris, 1993). CDR-SB is the sum of the six domain scores (memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care; range from 0 to 18). Key takeaways: Certain medications are linked to an increased risk of dementia. But that doesn’t mean they necessarily cause dementia. Medications that have been associated with increased risk of dementia include overactive bladder medications, pain medications, heartburn medications, and certain anxiety medications. While the evidence suggests that gabapentin alone does not cause memory loss, it can lead to brain fog or minor confusion. However, combining gabapentin with other drugs like baclofen can result in significant memory loss and impairment. Neurontin (gabapentin) is associated with memory loss in a dose dependent fashion, meaning the higher doses you take, the more chance there is of having some sort of memory loss, or cognitive impairment. For healthcare professionals. Applies to gabapentin: compounding powder, oral capsule, oral solution, oral tablet, oral tablet extended release. General adverse events. The most common adverse reactions associated with the use of this drug were dizziness, somnolence, and peripheral edema. Gabapentin, widely used for nerve pain and seizures, can cause memory issues in some users, such as forgetfulness or difficulty concentrating. Compared to pregabalin, which shares a similar mechanism, gabapentin’s cognitive effects are often considered milder, though this varies by individual.
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