does gabapentin help sleep apnea uptodate gabapentin dose

We hypothesized that gabapentinoids might be associated with sleep apnea syndrome. A recent pilot study reported a higher apnea–hypopnea index with gabapentin, supporting our hypothesis [5]. We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. Polysomnography measured the effects of the intervention. For individuals with sleep apnea, a condition characterized by repeated pauses in breathing during sleep, the use of gabapentin requires special consideration. Gabapentin and Sleep Apnea: Exploring the Connection and Treatment Options delves into the potential interactions between this medication and sleep-disordered breathing. Central sleep apnea (CSA) is a potentially serious and under-recognized adverse reaction of opioids, baclofen, valproic acid, sodium oxybate, gabapentin, and ticagrelor. CSA may be associated with impaired sleep quality, insomnia, nonrestorative sleep, impaired quality of life, fatigue, daytime sleepiness, and increased morbidity and mortality [2]. Gabapentin and sleep. Most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. Two small studies showed that gabapentin may help people with primary insomnia and occasional sleep disturbance improve total sleep time and wakefulness in the morning. Obstructive sleep apnoea (OSA) is characterized by repeated episodes of apnoea and hypopnoea during sleep. Little is known about the potential impact of therapy drugs on the underlying respiratory disorder. Any influence should be taken into account and appropriate action taken, including drug withdrawal if necessary. Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this systematic review and meta-analysis was to asse Some studies have found that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical restoration and cognitive function. Additionally, it may reduce sleep fragmentation, leading to fewer nighttime awakenings and improved sleep continuity. Understanding how gabapentin may affect sleep patterns is crucial in assessing its impact on sleep apnea symptoms and overall sleep quality. Gabapentin has been shown to influence sleep architecture in several ways. We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. The study found that gabapentin did not significantly worsen sleep apnea symptoms or increase the frequency of sleep apnea events. Another study published in The American Journal of Respiratory and Critical Care Medicine in 2019 investigated the effects of gabapentin on sleep apnea in patients with restless legs syndrome. Gabapentin Sleep Effects. Gabapentin is part of a class of medications known as anticonvulsants, which means it can decrease abnormal excitement in the brain.This medication is often prescribed for seizures but can also help with restless legs syndrome (RLS), insomnia, and even neuropathic pain caused by conditions like diabetes. This study revealed that without consideration of the type of sleep outcomes, gabapentin was significantly superior to placebos for the treatment for sleep disorders secondary to RLS, neuropathic pain, alcohol dependence, hot flashes in menopause, fibromyalgia, phantom limb pain, HIV-associated sensory neuropathies, and bipolar disorder. Like baclofen, some studies have shown that gabapentin might be of interest in alcohol dependence management [2]. In this context, baclofen is linked to sleep apnea syndrome [3, 4], aggravating sleep-disordered breathing by depressing central ventilatory drive and/or increasing upper airway obstruction. We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. 1993 and pregabalin was first approved in 2004. Gabapentin is marketed under the brand names Neurontin and Gralise, and also as generics. Gabapentin enacarbil is marketed under the brand name

does gabapentin help sleep apnea uptodate gabapentin dose
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