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The results revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all subgroups except for the strata having depression or head injury. The risk of dementia development was higher in the younger group (age <50 years) than that in the older group. The evidence of gabapentin and dementia is mixed, with two studies looking at hundreds of thousands of people and coming to completely different conclusions. Two common classes of drugs have been linked to dementia. Fortunately, there are alternatives to both. If you're worried about developing dementia, you've probably memorized the list of things you should do to minimize your risk—eating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. Objective: Previous studies have shown that gabapentin or pregabalin use is associated with cognitive decline. Herein, we aimed to evaluate the association between gabapentin or pregabalin use and the risk of dementia. Methods: In this retrospective, population-based matched cohort stu Dementia risk is tied to common things like diabetes, high blood pressure, and physical inactivity. But some common medications are associated with dementia risk, too. Here are four common drug classes linked to dementia, and what the research says about your risk. The adjusted odds ratio for dementia risk associated with gabapentin use was 0.91 (95 % C.I. 0.83–1.01), indicating no substantial increase in risk. Conclusion Long-term Gabapentin therapy for chronic pain is not associated with a differential risk of dementia across dosage levels, irrespective of age or gender. Most of the data to guide gabapentin use and dosing in older adults is from pharmacokinetic studies or case reports[1,2] While gabapentin is approved to prevent seizures, most patients take gabapentin for reasons of neuropathic pain (71%) or psychiatric disorders, with bipolar being most common (15%), with an average dose of 975 mg per day The high death toll of people with dementia in such facilities during the COVID-19 pandemic may increase that motivation, he notes. And the lack of information for clinicians on the use of these drugs in dementia makes every prescription a judgment call. 3.2 Functional status decline. The same sample was used for assessing functional status change as measuring cognitive decline ().At the first visit after index, the association of gabapentin initiation with functional decline was not significant for either change in FAQ sum (OR [95% CI]: 1.50 [0.76, 2.96]) or FAQ mean (1.56 [0.93, 2.63]). Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). The adjusted odds ratio for dementia risk associated with gabapentin use was 0.91 (95 % C.I. 0.83-1.01), indicating no substantial increase in risk. Conclusion: Long-term Gabapentin therapy for chronic pain is not associated with a differential risk of dementia across dosage levels, irrespective of age or gender. The short answer is: yes, emerging evidence suggests that gabapentin, and its close relative pregabalin, may indeed increase the risk of developing dementia, particularly with long-term use and higher cumulative doses. While it’s not a definitive “cause,” studies are highlighting a concerning correlation that warrants further Gabapentin, while effective for certain conditions, warrants careful consideration due to its association with an increased risk of dementia. Patients and healthcare providers should weigh the benefits and risks of gabapentin treatment, taking into account the potential cognitive side effects. The multivariate-adjusted hazard ratio of risk of dementia for gabapentin or pregabalin exposure versus the matched non-exposed group was 1.45 (95% confidence interval [CI], 1.36–1.55). The risk of dementia increased with higher cumulative defined daily doses during the follow-up period. Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood. There’s mounting evidence supporting a connection between certain medications (anticholinergics and benzodiazepines) and dementia. An expert discusses the latest research and what to do if you
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