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Do people take more than one medicine to ease migraine symptoms? In this study, two-thirds of migraine attacks were treated with just one drug. About a quarter of the study participants used two drugs, and a smaller number used three or more drugs. However, researchers weren't able to tease out the sequence of when people took the drugs. Does gabapentin (Neurontin) help prevent episodic migraine? Gabapentin does not decrease the frequency of migraine headaches and is not recommended for prophylactic therapy. Gabapentin for Migraine User Reviews Brand names: Neurontin, Gralise, Gabarone, Fanatrex Gabapentin has an average rating of 7.9 out of 10 from a total of 111 reviews for the off-label treatment of Migraine. The studies showed that neither gabapentin nor gabapentin enacarbil was more effective than placebo at reducing the frequency of migraine headaches. Gabapentin commonly caused side effects, especially dizziness and somnolence (sleepiness). No studies of pregabalin were identified, and research on this drug is desirable. There is some research to suggest that gabapentin can be helpful for migraine and headaches, though. One study from 2004 compared gabapentin with placebo as a preventive treatment option for people with migraine and found it to be an effective preventive agent. Preventive treatment can be preemptive, short term, or maintenance. Preemptive treatment is used when a known headache trigger exists, such as exercise or sexual activity. Patients can be instructed to pretreat prior to the exposure or activity. For example, a single dose of indomethacin can be used to prevent exercise-induced migraine. A 2016 study found that gabapentin showed some benefits for migraine headaches. However, it concluded that there wasn't enough evidence to recommend it as a primary therapy. Another study review in 2023 found that gabapentin was no more effective than a placebo in reducing monthly migraine days. We found moderate certainty evidence that beta-blockers, valproate, and amitriptyline increase the proportion of patients who experience a 50% or more reduction in monthly migraine days, and low certainty evidence that gabapentin may not be different from placebo. Recurrent migraines can be functionally disabling and can impair quality of life. The disabling nature of migraine headaches leads to frequent visits to outpatient clinics and emergency department facilities, causing significant health and financial burdens. Headaches fall in the top five causes of emergency department visits and the top twenty reasons for outpatient visits.[1] The overall Objective: Gabapentin (GBP), originally an antiepileptic drug, is more commonly used in the treatment of pain, including headache disorders. Off-label GBP is used in headache disorders with some success, some failure, and much debate. Gabapentin is an anticonvulsant used off-label to help prevent migraine attacks. Learn about why it’s used and how it works. The reasons for this are: (a) the definition of chronic migraine is still heavily debated, and a revision of the 2004 IHS criteria for this condition has been proposed (Olesen 2006); (b) transformed migraine and chronic daily headache, although commonly used terms, are insufficiently validated diagnoses; (c) the separation of these conditions GBP has some efficacy in migraine headache, but not sufficient evidence to suggest primary therapy. When primary headache treatments fail, a GBP trial may be considered in the individual patient. Gabapentin (Neurontin) is another that, while not specifically approved to prevent migraines, does work well for some people. Other drugs Although low-dose aspirin is far less effective than the standard migraine headache preventive medications, it may improve migraine control when used in combination with another preventive medication. Doctors sometimes use it “off-label” to prevent migraine attacks. Off-label means it isn’t FDA-approved to treat a condition, but your doctor can prescribe it to you if it’s used often in Preventive medication therapy reduces migraine frequency, severity, and headache-related distress. Preventive therapy may also improve quality of life and prevent the progression to chronic migraines.
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