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Review detailed drug interaction details between Diphenhydramine and Gabapentin, including severity, interaction details, how to manage the interaction, and more. Using diphenhydrAMINE together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Drug interactions between Benadryl and these specific antidepressants can increase the risk of side effects like drowsiness and reduced alertness. Diphenhydramine should not be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. See More information Regarding Diphenhydramine. Return To Our Drug Interaction Homepage It is important to inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are taking to avoid potential interactions. Drug Interactions Medications that may interact with gabapentin. Gabapentin can interact with several medications, leading to different effects. Benadryl, an antihistamine, and Gabapentin, an anticonvulsant, can have additive effects on the central nervous system. 1. Increased Drowsiness: Both Benadryl and Gabapentin can cause drowsiness as side effects. Taking them together may intensify this effect, making you feel exceptionally sleepy or fatigued. 2. Applies to: Benadryl (diphenhydramine) and gabapentin. Using diphenhydrAMINE together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Drug interactions are reported among people who take Gabapentin (gabapentin) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include pyrexia among females and fatigue among males. Applies to: Benadryl (diphenhydramine) and Neurontin (gabapentin) Using diphenhydrAMINE together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Taking Benadryl With Gabapentin. Gabapentin is used for a wide variety of indications such as neuropathy and epilepsy. Gabapentin is a CNS depressant. Concurrent use of 2 or more drugs that can cause CNS depression (such as with Benadryl) may increase the chance of side effects, such as: Increased drowsiness; Sedation; Confusion; Respiratory A phase IV clinical study of FDA data: drug interactions are found among 2,435 people who take Gabapentin (gabapentin) and Diphenhydramine hydrochloride (diphenhydramine hydrochloride). Compare Diphenhydramine vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. The interaction between gabapentin and Benadryl is a significant concern due to the enhanced sedative effects. Combining these medications can result in dangerous side effects such as excessive drowsiness, dizziness, confusion, and impaired coordination. Ask your doctor before using acetaminophen together with ethanol (alcohol). This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. The following applies to the ingredients: Diphenhydramine (found in Benadryl) and Gabapentin MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another The following applies to the ingredients: Diphenhydramine (found in Benadryl) and Gabapentin. Using diphenhydrAMINE together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Ask your doctor or pharmacist to check your drugs for any important drug interactions. Learn how to recognize the effects of any drug interactions. In case of a drug interaction, learn when you should call your doctor or 911 for emergency help. All medicines come with written instructions. Follow those directions closely. 7 diphenhydramine interactions to know about There are many possible interactions with diphenhydramine. Below, we’ll go over some common ones to watch out for. Keep in mind that this isn’t a complete list. For your safety, always ask your pharmacist or healthcare provider about possible interactions.
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