drug interactions with gabapentin enacarbil white gabapentin 600 mg

Gabapentin enacarbil is neither a substrate nor an inhibitor of P-glycoprotein in vitro. Pharmacokinetic drug-drug interaction studies were conducted to examine the potential for an interaction of gabapentin enacarbil with cimetidine and naproxen. No significant pharmacokinetic interactions were observed. gabapentin enacarbil decreases levels of levocarnitine by unspecified interaction mechanism. Minor/Significance Unknown. pancuronium. gabapentin enacarbil decreases effects of pancuronium by pharmacodynamic antagonism. Minor/Significance Unknown. rapacuronium. gabapentin enacarbil decreases effects of rapacuronium by pharmacodynamic antagonism. Drug Interactions. Alcohol (Ethyl): May enhance the CNS depressant effect of Gabapentin Enacarbil. Alcohol (Ethyl) may increase the absorption of Gabapentin Enacarbil. Specifically, the rate of absorption may be enhanced, as alcohol may speed the release of drug from the extended-release tablet. Avoid combination There are 270 drugs known to interact with Horizant (gabapentin enacarbil), along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 28 are major, 232 are moderate, and 10 are minor. Gabapentin enacarbil is a Gamma-aminobutyric acid analogs used to treat Postherpetic Neuralgia and Restless Legs Syndrome (RLS). There are 270 drugs known to interact with gabapentin enacarbil, along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 28 are major, 232 are moderate, and 10 are minor. Gabapentin Enacarbil has minor interactions with at least 17 other drugs. This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. There are 4 disease interactions with gabapentin enacarbil. Major Potential Hazard, Moderate plausibility. Applicable conditions: Drug Abuse/Dependence. Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. The presence of other medical problems may affect the use of this medicine. Drug Interactions. Neither gabapentin enacarbil nor gabapentin are substrates, inhibitors, or inducers of the major cytochrome P450 enzymes. Gabapentin enacarbil is neither a substrate nor an inhibitor of P-glycoprotein in vitro. Drug Interactions between Celebrex and gabapentin enacarbil. This report displays the potential drug interactions for the following 2 drugs: Celebrex (celecoxib) gabapentin enacarbil; Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs To examine the potential for drug–drug interactions at these two transporters, the pharmacokinetics of gabapentin enacarbil were evaluated in healthy adults after administration alone or in combination with either naproxen (an MCT-1 substrate) or cimetidine (an OCT2 substrate). Taking Horizant with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures. Other drugs may interact with gabapentin enacarbil, including prescription and over-the-counter medicines, vitamins, and herbal products. Compare Gabapentin vs Gabapentin Enacarbil head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Gabapentin is an anti-epileptic drug, also called an anticonvulsant. (gabapentin enacarbil) Not all possible drug interactions are listed here. From drug interaction studies conducted with GEn versus cimetidine and naproxen, there appears to be no significant pharmacokinetic interactions. No drug interactions are anticipated between GEn and substrates of the organic cation transporter type 2 (OCT2) or monocarboxylate transporter type 1 (MCT-1). Drug-Lab Interactions Drug. Interaction. Comments. Alcohol. Increases risk of sedation/somnolence, dizziness. Causes rapid release of drug from gabapentin enacarbil extended-release tablets. Avoid concomitant use. Antacids. Reduced bioavailability of gabapentin, but to a smaller extent when gabapentin administered 2 hours after antacid Drug Interactions between gabapentin enacarbil and Wellbutrin XL. This report displays the potential drug interactions for the following 2 drugs: gabapentin enacarbil; Wellbutrin XL (bupropion) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs See the Interactions section for more details. Tell your healthcare provider if you develop severe sleepiness, especially when you start Horizant or when your dose is increased. Gabapentin enacarbil does not interact with any of the major cytochrome P450 enzymes. Gabapentin enacarbil is eliminated primarily in the urine (94%) and to a lesser extent in the feces (5%). The elimination half-life of gabapentin is 5.1 to 6.0 hours.

drug interactions with gabapentin enacarbil white gabapentin 600 mg
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