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earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and Fortunately, a new treatment option may be able to treat hot flashes without the risk. Gabapentin, an anticonvulsant, may be effective for the treatment of hot flashes. Often sold as Neurontin, gabapentin is approved by the Food and Drug Administration (FDA) for the treatment of epilepsy. The hot flashes almost stopped completely after just 1 week of taking this medicine. The study lasted for 6 months, and then I was taken off cold turkey. The withdrawal was horrible. Hot flashes, couldn't sleep, and just overall irritable to say the least. I went to my regular doctor and was prescribed gabapentin 600mg. Again the hot flashes Gabapentin is an antiseizure medication that some people use for hot flashes. While the FDA has not approved this medication for hot flashes, it is an effective option for some individuals. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. In the present study, gabapentin 300 mg/day significantly decreased hot flash frequency and severity similar to that observed for estrogen. But gabapentin 100 mg/day had mildly decreases on frequency and intensity of hot flash. Gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women, but there was substantial variation in the results across the included trials. The authors' conclusions appear to be reliable based on the evidence presented. In studies, gabapentin reduced hot flashes from 45%-71% depending on the dose. In one, albeit small, clinical trial 2,400 mg of gabapentin divided three times a day was as effective as 0.625 mg of Premarin a day (which is a standard dose for hot flashes). How to Take Gabapentin? At doses used to control hot flashes, gabapentin was well tolerated, with drowsiness as its most reported adverse effect. Gabapentin can be considered effective in the treatment of hot flashes and should be considered a reasonable alternative when estrogen therapy is not desired. Subgroup and meta-regression analyses of gabapentin dosage were performed. Results: We included seven randomized controlled trials that compared single-agent gabapentin with placebo for treating hot flushes in the meta-analysis. Women who received gabapentin reported a significantly greater reduction in the frequency (SMD 2.99 [95% confidence Gabapentin presents a promising option for managing hot flashes, particularly for those who haven’t found relief through other treatments. By understanding its benefits, potential side effects, and proper administration, you can make informed decisions about its use. Based on the anecdotal information, the current phase 2 clinical trial was developed to more definitively evaluate gabapentin's efficacy against hot flashes and its associated toxicity. The results of this randomised, double-blind placebo-controlled trial accord with those of our pilot study of menopausal women; 21 there was a 46% reduction in the hot-flash severity score with gabapentin 900 mg/day, compared with a 54% reduction versus placebo reported in postmenopausal women treated with gabapentin 900 mg/day for 12 weeks. 20 Gabapentin Brand name: Neurontin® available as 100mg, 300mg, 400mg, 600mg and 800mg capsules. Also available in generic brands. Gabapentin is usually used to control epilepsy or chronic nerve (neuropathic) pain. It is also a non-hormonal medicine that has been shown to be effective in reducing menopausal hot flushes. Gabapentin appears to be To decrease sedation, it is preferable to start with 100 mg daily with gradual increase by 100 mg every 3 days to maximally effective or tolerated dose. While switching therapy from SSRI/SNRI to gabapentin, it is preferable to continue SSRI/SNRI for 1 st 2 weeks while gabapentin is being introduced and taking its full effect. Other agents that have been used to alleviate hot flashes include belladonna/ergotamine tartrate/phenobarbital combination, dong quai, evening primrose oil, gabapentin, ginseng, mirtazapine
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