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CrCl 30 to 59 mL/min: Initial dose: 300 mg orally once a day for 3 days, then 300 mg orally 2 times a day; increase to 600 mg orally 2 times a day as needed; CrCl 15 to 29 mL/min: Initial dose: 300 mg orally in the morning on day 1 and day 3; then 300 mg once a day in the morning; may increase to 300 mg orally 2 times a day if needed The most effective dose of gabapentin for treating pain relating to postherpetic neuralgia from shingles will be determined by working with your doctor. Your doctor will likely start you on a base dosage and work up to the dosage that works best for you. Duration of Treatment: Gabapentin is taken for 7 to 14 days for shingles pain. Dosage Guidelines: Initial doses start low, increasing based on tolerance. Consult Healthcare Providers: Always discuss treatment options and adjustments. Pain Management: Gabapentin effectively reduces postherpetic neuralgia pain. Lifestyle Modifications:Lifestyle Gabapentin is approved to prevent and control partial seizures, relieve postherpetic neuralgia after shingles and moderate-to-severe restless legs syndrome. Learn what side effects to watch for, drugs to avoid while taking gabapentin, how to take gabapentin and other important questions and answers. Gabapentin can help relieve nerve pain in some people with postherpetic neuralgia (nerve pain after shingles) and peripheral diabetic neuropathy (nerve pain in the feet in people with diabetes). Gabapentin is taken by mouth and is available either as a capsule (100 mg, 300 mg, and 400 mg) or a tablet (600 mg and 800 mg). Gabapentin can be taken with or without food. When used for pain, gabapentin is prescribed at a lower "loading dose" and gradually increased to the optimal "therapeutic dose." If you have impaired kidney function, taking a lower dose or spacing out the dosing time is essential to prevent unwanted side effects.; Taking gabapentin with opioids (e.g., morphine, hydrocodone) can cause respiratory depression and sedation, and lead to fatal outcomes. Gabapentin is an anticonvulsant with pain-relieving effects that may be used to treat partial-onset seizures or relieve nerve pain. Research has shown gabapentin binds strongly to a specific site (called the alpha2-delta site) on voltage-gated calcium channels and this is thought to be the way gabapentin works to relieve nerve pain and lower Gabapentin is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. The typical starting dosage of gabapentin for seizures is 300 mg by mouth three times a day, with or without food. Your prescriber may adjust your gabapentin dosage to up to 600 mg 3 times a day (1,800 mg per day). The maximum gabapentin dosage is 3,600 mg per day, but higher doses are more likely to cause side effects.Restless legs syndrome Initial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three Maintenance dose: 300 to 600 mg orally 3 times a day Maximum dose: 3600 mg orally daily (in 3 divided doses)-Maximum time between doses in the 3 times a day schedule should not exceed 12 hours Comment: The usual dose of gabapentin for shingles (post herpetic neuralgia) in adults is a 300-milligrams (mg) single dose on day 1, 300 mg twice a day (total 600 mg) on day 2, and 300 mg three times a day (total 900 mg) from day 3 onwards. The dose can be increased as needed for pain relief, up to 600 mg three times a day (total 1,800 mg/day).
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