Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat neuropathic pain and also for partial seizures [10] [7] of epilepsy. It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy , postherpetic neuralgia , and central pain . [ 11 ] Gabapentin is an anti-convulsant medication that inhibits the release of excitatory neurotransmitters, allowing for its use against pathologic neurotransmission such as that seen in neuropathic pain and seizure disorders. It has a wide therapeutic index, with doses in excess of 8000 mg/kg failing to cause a fatal reaction in rats. Other medications, such as antidepressants and sedatives, may also interact with gabapentin and can increase the risk of drowsiness and dizziness. It is important to inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are taking to avoid potential interactions. Medscape - Seizure dosing for Neurontin, Gralise (gabapentin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost Gabapentin's mechanism of action is complex and not fully understood. It's thought to work by binding to certain receptors in the brain and spinal cord, which helps to regulate the activity of neurotransmitters, particularly GABA. This complex interaction contributes to its effectiveness in treating seizures, nerve pain, and other conditions. Generic name: gabapentin Dosage with other CNS depressants. Gabapentin can be removed by hemodialysis. parameters for phenobarbital or gabapentin (300 mg Brand names of gabapentin include Horizant®, Gralise® and Neurontin®. What is gabapentin approved for? Gabapentin is used to: Prevent and control partial seizures. Gabapentin can be used in adults and children age 3 and older who have partial seizures. Relieve nerve pain following shingles in adults. Gabapentin is marketed as Neurontin, Gralise and Horizant and is also available as a generic. Pregabalin is sold under the brand name Lyrica and Lyrica CR. The FDA warns that use of the drugs along with opioid pain medicines or other drugs that depress the central nervous system can severely weaken breathing or cause death. In addition to these FDA-approved uses, doctors sometimes prescribe gabapentin off-label. Off-label use means there is some evidence to show that a drug may be medically appropriate to treat conditions other than those for which it was approved. Gabapentin is sold under the brand name Neurontin and is available as a generic product as well. Generic Name Gabapentin DrugBank Accession Number DB00996 Background. Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid that was first approved for use in the United States in 1993. 16 It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures 14,5 - today it is also widely used to treat neuropathic pain. 8 Gabapentin is commonly used to treat and prevent seizures in people with epilepsy or to treat nerve pain (postherpetic neuralgia) that can occur after a viral infection called shingles. Gabapentin is a prescription drug most commonly prescribed to relieve nerve pain following shingles in adults and the pain of postherpetic neuralgia. Learn about side effects, drug interactions, dosages, warnings, and more. Lists the various brand names available for medicines containing gabapentin. Find information on gabapentin use, treatment, drug class and molecular formula. Neurontin: Gabapentin belongs to the class of medications called anti-epileptics. It is used in combination with other seizure control medications to manage and prevent seizures associated with epilepsy. Gabapentin does not cure epilepsy and only works to control seizures as long as the medication is taken. Gabapentin works by affecting the transmission of nerve signals in the brain. Initial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three Maintenance dose: 300 to 600 mg orally 3 times a day Maximum dose: 3600 mg orally daily (in 3 divided doses)-Maximum time between doses in the 3 times a day schedule should not exceed 12 hours Comment: Gabapentin (Neurontin, Gralise, Horizant) is a medicine used to treat partial seizures, nerve pain from shingles and restless leg syndrome. It works on the chemical messengers in your brain and nerves. Gabapentin is from a group of medicines called anticonvulsants. Gabapentin is used to help control partial seizures (convulsions) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. Gabapentin is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. Discover the commercial and brand names of the generic drug Gabapentin. This indispensable guide is essential for healthcare professionals, patients, caregivers, and anyone seeking to Gabapentin enacarbil (brand name Horizant) is a prodrug of gabapentin that has been designed to overcome the limitations of gabapentin, such as poor absorption and a short duration of action. It requires hydrolyzation in the gastrointestinal tract to become active. Gabapentin belongs to the group of medicines known as anticonvulsants. 2. Upsides An unusual or allergic reaction to gabapentin, other medications, foods, dyes, or preservatives; Pregnant or trying to get pregnant; Breast-feeding; How should I use this medication? Take this medication by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food.
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