A recent survey using the US-based TriNetX electronic health records network showed that gabapentin had been prescribed at least once in 13.6% of patients with bipolar disorder (BD), 11.5% with anxiety disorders, and 12.7% with insomnia disorder; for pregabalin, the figures were 2.9%, 2.6%, 3.0% respectively (PJH, unpublished observations). Some research suggests that Gabapentin can effectively alleviate anxiety symptoms in some people. That said, the efficacy of this prescription medication can vary from person to person. It’s important to know that Gabapentin is not FDA-approved specifically for the treatment of anxiety. While gabapentin is increasingly being used to treat generalized anxiety disorder (GAD), little is known about its effectiveness on GAD symptoms. The patient presented here has a relatively straightforward psychiatric history, with GAD playing a prominent role. Recent research indicates that gabapentin has proven to be an effective treatment for anxiety sufferers. Nevertheless, there are few case reports and no randomized controlled trials regarding this medication’s efficacy in treating generalized anxiety disorder (GAD). Preclinical data suggest the potential anxiolytic effect of gabapentin ().Recently, Beauclair et al. reported reduction in anxiety symptoms and syndromes in 18 patients with primary psychotic disorders and in one patient with generalized anxiety disorder treated adjunctively with gabapentin, 200–1800 mg/day. Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use disorder. There is sufficient evidence to consider gabapentin as a third-line treatment for social anxiety disorder and severe panic disorder. In recent years, gabapentin has gained attention for its potential role in managing anxiety disorders, particularly for individuals who do not respond well to traditional anxiety medications like SSRIs or benzodiazepines. Gabapentin isn’t usually used to treat anxiety alone. More often, it’s given to ease anxiety symptoms for someone who also has depression or bipolar disorder. (Anxiety is commonly Gabapentin (Neurontin) is FDA approved to treat seizure disorder and nerve pain from shingles. But it’s also used off-label to treat many other conditions, including anxiety, nerve pain from diabetes, and hot flashes. Although evidence is limited, some studies show gabapentin can help with anxiety symptoms. One 2020 review suggests gabapentin may help with different types of situational anxiety, One medication that is being used off-label for anxiety is called gabapentin. Here we’ll look at the use of gabapentin for anxiety, and explore the pros and cons of this protocol. What is Gabapentin? Gabapentin belongs to the group of drugs called anticonvulsants, sold under the brand name Neurontin to treat chronic nerve pain. A small randomized, controlled trial suggested that adjunctive gabapentin accelerates therapeutic response to fluoxetine in patients with obsessive-compulsive disorder. 32 In a randomized, controlled trial of 420 breast cancer survivors with nonspecific anxiety symptoms, 8 weeks of treatment with gabapentin 300 mg produced significant There is mounting evidence that Gabapentin may be an effective intervention for various types of anxiety including: generalized anxiety disorder, social anxiety disorder, and panic disorder. Gabapentin for Anxiety Disorders: The Research. There is considerable research documenting the efficacy and safety of Gabapentin for anxiety disorders. Whether you’re already taking gabapentin for an anxiety disorder or are curious if you might benefit from it, you may be wondering how effective it is, how it works, and if there are side effects. Here we’ll cover everything you need to know about gabapentin for anxiety. Bipolar disorder (BD) Four DB-RCTs investigating the efficacy of gabapentin in BD were identified. 101 patients were randomised to receive gabapentin, 81 to placebo, 30 to lamotrigine and 19 to Gabapentin appears to have some benefit for anxiety disorders but failed to show benefit in bipolar disorder trials. In the individual patient with a mixed psychiatric disorder, benefits are most likely due to anxiolytic effects.
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