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In addition to aggressive fluid resuscitation and preparation providing a significant amount of sodium, drug-induced oedema entails four mechanisms (Figure 2), namely precapillary arteriolar vasodilation (vasodilatory oedema), sodium and/or water retention (renal oedema), lymphatic insufficiency (lymphedema) and increased capillary permeability Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. Studies have suggested that gabapentin may interfere with the RAS, leading to an imbalance in fluid regulation. Increased fluid retention can cause edema in certain individuals receiving gabapentin therapy. Hello! I have been on Gabapentin for Neuropathic back pain only for one month and am at the max dose of 3600 mg a day. It is helping with the pain however I am seeing the water retention. I work out daily and my clothes fit tighter and I can see swelling in my legs and abdominal bloat. Gabapentin side effects are usually mild, and they may be less common with gabapentin ER forms. Examples of mild side effects that can happen include: Vertigo (dizziness) Feeling fatigued or sleepy. Fluid retention. Trouble balancing or controlling movement. Diarrhea or constipation. Nausea and vomiting. Brain fog. Headache. Weight gain. Dry mouth Seven days after the administration of the gabapentin, the patient complained from pain and edema and scaling and hyperesthesia in his lower extremities and pitting edema, pain and tenderness. The range of motion of the extremities was been increased. According to the patient statement the gabapentin brand has been changed. Gabapentin is a medication used to treat seizures, restless legs syndrome, and nerve pain from shingles. Some people taking it report fluid retention and swelling in their extremities. Swelling may be more likely if you’re older, or if you’re taking a higher gabapentin dosage. Gabapentinoids can cause concentration-dependent peripheral edema of early onset. Reduced myogenic tone is the main mechanism of these non-cardiogenic edemas. In case of peripheral edema or heart failure, a drug etiology should be considered. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. Swelling from fluid retention may be reduced by: Sitting with your feet raised; Avoiding standing for long periods of time; If gabapentin is causing you to gain weight, do not stop taking this drug on your own. Stopping the drug suddenly can lead to serious problems, especially if you are taking gabapentin for seizures. Fluid Retention. One common reason for swelling is fluid retention. Gabapentin can cause changes in kidney function or fluid balance in the body. When the body retains excess fluid, it can lead to noticeable swelling in areas like the legs, ankles, or hands. Allergic Reactions. In rare cases, swelling may result from an allergic reaction to This is a case of delayed identification of a probable adverse drug reaction to gabapentin (Naranjo score of 5) consisting of painful, 4+ pitting bilateral edema and a clear dose relationship in a patient with pervasive developmental disorder and schizoaffective disorder. Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect of another drug. Fluid retention is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Furosemide, and have Depression. Gabapentin can cause fluid buildup in the legs (edema), which can lead to temporary weight gain. You can also gain weight without fluid buildup, though it’s not common. You may be able to avoid weight gain from gabapentin by adjusting your diet and exercising regularly. Yes, gabapentin may cause fluid retention and induce edema in arms and legs. Experts believe that this side effect can also be the reason for weight gain by increasing your water weight. It can also make the body look bulky. Gabapentin induced edema, just like calcium channel blockers induced edema, is not associated with salt and water retention and hence diuretics are ineffective. Physicians, especially nephrologists, should be mindful of uncommon side effect of this commonly prescribed medication as distinguishing this early can prevent a lot of unnecessary work No change in diet, not eating any more than I did before. Therefore, I'm chalking it down to a mix of slower metabolism and water retention. I have never been as heavy in my life, I absolutely hate this drug, but coming off it is much harder than I anticipated. I'm starting the process of tapering down. Gabapentin does help with the pain but, I don’t like the swelling. It also makes me drowsy but I sleep good. The drug has pros and cons about it. I have been on it for about 8.5 years with no fluid retention or other side effects. Thanks for your response but Im not 100% convinced that is true. Fluid retention, or edema, can occur when gabapentin affects vascular permeability or alters kidney function. Edema refers to swelling caused by excess fluid accumulation in tissues. It can occur in various parts of the body but is most commonly seen in the legs, ankles, and feet.
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