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Abstract Simple Summary. Adjusting drug dosages in dogs and cats with chronic kidney disease (CKD) can be challenging in clinical practice due to the lack of specific indications in the current literature; moreover, the evaluation of renal function through the measurement of glomerular filtration rate (GFR), which is unanimously considered as a requisite for most adjustment strategies, is Gabapentin is excreted by the kidneys, so animals with kidney disease are more susceptible to effects of overdose. What are the most common side effects of gabapentin in dogs? The most common side effects include sedation (sleepiness) and incoordination. However, the effects may persist longer in dogs with liver and kidney disease. Therefore, Gabapentin should be used with caution in dogs with: Liver and kidney problems ; Young puppies ; Pregnant and lactating female dogs; On the other hand, Gabapentin should not be used at all in dogs: Allergic to the active ingredient ; Receiving meds with Gabapentin for dogs is an anti-seizure and pain medication commonly prescribed to dogs by veterinarians. Gabapentin for dogs may be helpful for treating chronic pain especially nerve pain that is secondary to neurological diseases such as slipped discs. The most common side effects of gabapentin in dogs include sedation and dizziness. Gabapentin should also be used with caution in animals with kidney or liver disease, as it will take longer to metabolize. What's the Gabapentin Dosage for Dogs? The dosage range for gabapentin varies widely depending on what it’s being used to treat. When Is It Contraindicated to Use Gabapentin in Dogs? Because gabapentin is predominantly excreted by the kidneys, dogs with kidney disease should not be treated with gabapentin. Kidney Disease: Although gabapentin isn’t primarily metabolized by the liver, it is cleared through the kidneys, so dogs with kidney disease might require lower doses to avoid adverse effects. Gabapentin should be used cautiously in dogs with kidney disease, pregnant dogs, lactating dogs, and dogs with a known allergy to the medication. It should also not be abruptly stopped in epileptic dogs due to the risk of withdrawal seizures. Recent studies have confirmed the efficacy of both drugs for treating OA pain in cats. 14,18 Large studies of the clinical safety of robenacoxib have been published and demonstrate its safety in older cats, even those with chronic kidney disease. 105 A recent review emphasized that fears over the long-term use of NSAIDs in cats, including those Gabapentin: Gabapentin is often used for nerve pain and is safe for dogs with kidney disease. It is typically used to manage conditions like arthritis, spinal issues, and post-surgical pain. It does not have significant effects on kidney function, making it a reliable option. While gabapentin itself isn’t directly damaging to the kidneys, it can be harder for a dog with kidney disease to clear it from their system. This could lead to a buildup and increase the risk of side effects. Q: What Medications Should Be Used in Dogs With Elevated Liver Enzymes and Chronic Kidney Disease? Elevated Liver Enzymes It has been shown that, in the absence of liver dysfunction, elevated liver enzymes—serum alkaline phosphatase (ALP) and/or alanine aminotransferase (ALT)—are not necessarily a contraindication to the administration of 🐾 Is Gabapentin Safe for All Dogs? Gabapentin is safe for most dogs when used correctly, but it may not be suitable for every pet. Dogs with specific health conditions or on certain medications require extra caution. When to Be Cautious: Liver or Kidney Disease: Gabapentin is processed by these organs, so dosage adjustments may be necessary. Most dogs are prescribed gabapentin to manage chronic pain associated with arthritis and cancer as well as neural and post-operative pain. It’s often prescribed alongside NSAIDs or opiates. It’s thought to amplify their effect on pain management despite potential side effects. Although dogs with kidney disease may need a lower dose due to slower excretion, gabapentin does not seem to have adverse effects on the kidneys like NSAIDs do. One of the drawbacks to gabapentin as a pain medication, however, is that it does not have anti-inflammatory effects like NSAIDs do. Dogs have higher basal levels of COX-2 expression in the kidney than humans. In dogs with chronic kidney disease, COX-2 expression increases and synthesis of prostaglandins shifts to the COX-2 pathway. Therefore, NSAIDs that target COX-2 may adversely affect renal function in dogs with chronic kidney disease. 13 Although gabapentin is only metabolized through the kidneys in humans, research shows that in dogs it’s metabolized through both the kidneys and liver. So dogs with kidney or liver problems Gabapentin itself is not known to directly cause kidney damage in dogs. However, it’s essential to understand that the way gabapentin is processed in a dog’s body means that kidney health plays a vital role in how the drug works and whether dose adjustments are necessary. Gabapentin should be USED WITH CAUTION in pets that: have kidney disease; are pregnant and/or lactating ; Do not stop this medication abruptly in pets with epilepsy, as this can cause withdrawal seizures. Some liquid oral formulations contain xylitol, a sugar substitute that is toxic to dogs, so be cautious and read the label before administering. Background: Gabapentin is frequently used as an analgesic in patients with chronic kidney disease. Although gabapentin is well known for its favorable pharmacokinetics, it is exclusively eliminated renally, and patients with chronic kidney disease are at risk for toxicity.
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