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Gabapentin and lamotrigine are only now being evaluated in controlled trials in patients who have bipolar disorder. Antipsychotics are commonly used in the treatment of patients with acute mania and as maintenance treatment. However, the use of standard antipsychotics in acute mania is associated with a number of limitations. Flowchart of included and excluded studies. Bipolar disorder (BD) Four DB-RCTs investigating the efficacy of gabapentin in BD were identified. 101 patients were randomised to receive gabapentin, 81 to placebo, 30 to lamotrigine and 19 to carbamazepine. N2 - Certain anticonvulsants, in particular valproate and carbamazepine, that were initially used to treat epilepsy have subsequently been found to be effective in the treatment of psychiatric disorders, especially bipolar disorder. Gabapentin and lamotrigine are two new anticonvulsants that appear to have mood stabilizing properties. Lamotrigine: Despite the recent ap-proval of lamotrigine for the treatment of bipolar disorder, there are very few studies of its combination with other approved agents, such as lithium, di-valproex, and atypical antipsychotics. Gabapentin Bipolar Disorder Study Group. Bipolar Disord. 2000 Sep;2(3 Pt 2):249-55. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Extrapolation of postulated mechanisms of anticonvulsant activity in bipolar disorder has led to the use of the newer anticonvulsants gabapentin and lamotrigine for therapy. Both agents appear promising on the basis of limited (often anecdotal) evidence. This paper reviews the experience to date with these agents in the treatment of psychiatric conditions. Gabapentin demonstrates promise for the treatment of panic and generalized anxiety, while both gabapentin and lamotrigine appear useful as mood stabilizers in the treatment of bipolar disorder. Two new anticonvulsants, lamotrigine and gabapentin, have been used increasingly for bipolar disorder in the past several years. Despite this array of options, bipolar disorder remains a difficult disorder to treat. Some subtypes, such as those characterized by rapid cycling or mixed episodes, have been especially resistant to lithium treatment. The utility of gabapentin and lamotrigine for the treatment of bipolar disorder is reviewed. Bipolar disorder is characterized by extreme mood fluctuations, including mania, hypomania, depression, and mixed episodes. Aims: The efficacy of the anticonvulsants valproate, lamotrigine and gabapentin in bipolar disorder is reviewed. Method: Using Medline ® and other sources of information, 12 double-blind controlled studies with either of these compounds were identified. This paper reviews published evidence on the effects of the new anticonvulsants gabapentin and lamotrigine in bipolar disorder. The conclusion is that there is good evidence from open studies to indicate that randomised double-blind trials of these compounds should be carried out. I have Bipolar 2 and have been on Lamictal/Lamotrigine for 10 years now, and 6 weeks ago was put on Gabapentin for spinal stenosis. I was also concerned about combining the two. ST Certain anticonvulsants, in particular valproate and carbamazepine, that were initially used to treat epilepsy have subsequently been found to be effective in the treatment of psychiatric disorders, especially bipolar disorder. Gabapentin and lamotrigine are two new anticonvulsants that appear to have mood stabilizing properties. Lamotrigine has been suggested as effective in the treatment of comorbid bipolar and borderline personality disorder (Preston et al 2004), comorbid bipolar disorder and alcohol dependence (Rubio et al 2006), and comorbid bipolar disorder and cocaine dependence (Brown et al 2003; Brown E et al 2006). However, these studies all have limited Botts SR, Raskind J. Gabapentin and lamotrigine in bipolar disorder. Am J Health Syst Pharm 1999; 56:1934-44. 29. Fatemi SH, Rapport DJ, Calabrese JR, Thuras P. Lamotrigine in rapid cycling bipolar disorder. J Clin Psychiatry 1997; 58:522-7. 30. Bipolar Disorder / drug therapy* Clinical Trials as Topic Cyclohexanecarboxylic Acids* Gabapentin Humans Lamotrigine Two new anticonvulsants, lamotrigine and gabapentin, have been used increasingly for bipolar disorder in the past several years. Despite this array of options, bipolar disorder remains a difficult disorder to treat. On the basis of the Clinical Global Impressions Scale for Bipolar Illness (CGI-BP), lamotrigine was superior in reducing symptoms versus gabapentin and placebo. 20 Obrocea et al 21 also found gabapentin and placebo inferior to lamotrigine in a crossover study of 35 patients with bipolar disorder and 10 patients with unipolar disorder for Four DB-RCTs investigating the efficacy of gabapentin in BD were identified. 101 patients were randomised to receive gabapentin, 81 to placebo, 30 to lamotrigine and 19 to carbamazepine. Learn about medications for bipolar disorder treatment, including lamotrigine, gabapentin, topiramate, and calcium channel blockers. Understand their efficacy, side effects, and benefits for patients.
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