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Yes, gabapentin can affect appetite, and often in a way that leads to increased hunger. While not everyone experiences this side effect, it’s a notable concern for some individuals taking this medication. In short, **gabapentin primarily tends to increase appetite** in many individuals, rather than decrease it. This side effect can lead to weight gain if dietary habits and exercise routines are not adjusted accordingly. Increased appetite: By lowering blood sugar levels, gabapentin may increase appetite and make you feel hungry more often than usual. Eating frequently or eating a high-calorie diet can contribute to weight gain. Swelling: In clinical trials, gabapentin causes peripheral edema (swelling in the limbs), which can lead to increased body weight. I experience loss of appetite while taking Gabapentin. At first I would see triggers such as a photo of food or some food smelled tasty and think, "boy, I'd like that" but immediately after I'd think-"but I'm not hungry". Gabapentin was compared with mirtazapine in this study because of the latter’s demonstrated appetite-stimulating effect in cats: the same dose of 1.88 mg/cat PO used in the present work showed positive effects on appetite, weight gain and reduction of vomiting in cats with CKD. 31 In the cited study, appetite was documented by the owners via The Food and Drug Administration first approved Neurontin (gabapentin) in 1993 to treat epilepsy. Anticonvulsants are not normally blockbuster drugs. Perhaps that is why the original manufacturer, Parke-Davis, promoted the drug off-label to treat pain. Typically, in adult patients, the half-life of gabapentin is between 5 and 7 hours. This means that after that time, the concentration of gabapentin in the body will be reduced by half. It can take several half-lives for gabapentin to leave the body entirely. In general, after 1 to 2 days, there will be no gabapentin left in your system. No statistically significant difference was found between cats treated with gabapentin or mirtazapine. Conclusions and relevance: Cats receiving gabapentin ate more than cats in the placebo group. Thirty percent of cats in the gabapentin group covered their resting energy requirements, while none of the cats in the placebo group did. Yes, gabapentin can significantly change your appetite. While it’s primarily known as an anticonvulsant and nerve pain medication, gabapentin often leads to an increase in appetite for many individuals. There are many theories in regards to why you may pack on some extra poundage while taking Gabapentin. Appetite increase: Some people notice that Gabapentin significantly increases their appetite. If you’ve been taking Gabapentin and have been feeling hungrier than usual, it may be more than a coincidence. Gabapentin may affect appetite regulation through its interaction with various neurotransmitters; Some studies suggest it can increase appetite, leading to weight gain. Conversely, the cessation of gabapentin might restore normal appetite regulation, facilitating weight loss. This occurs in around 8% of patients taking gabapentin. 1. Gabapentin may cause weight gain by increasing your appetite, causing fluid retention, and inhibiting physical activity by causing fatigue. Because gabapentin is an anticonvulsant, it prevents seizures and nerve pain by reducing nerve activity in the central nervous system. Check with your doctor immediately if any of the following side effects occur while taking gabapentin: More common in children. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Gabapentin and Appetite: The Real Story. While gastrointestinal distress, such as loss of appetite, vomiting, and diarrhea, are listed as possible side effects, the most commonly reported side effects are sedation and loss of coordination (ataxia). The most common gabapentin (Neurontin) side effects are dizziness and drowsiness. This may affect your ability to drive or perform other activities. Other gabapentin side effects include edema (fluid buildup), weight gain, and eye problems, but these aren’t as common. Gabapentin (Neurontin) is a medication that’s FDA approved to treat seizures and postherpetic neuralgia (nerve pain from shingles). Gabapentin can potentially cause weight gain, usually due to peripheral edema, a common side effect. This refers to swelling in the ankles and feet due to fluid retention. Appetite decreased is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Multiple myeloma. Ever since I started on gabapentin I have almost entirely lost my appetite. I eat like one meal a day and it’s to the point that the prospect of eating in general is just really unappealing. It’s like getting hard to enjoy eating. Appetite suppression: Gabapentin has been shown to decrease appetite in some individuals, potentially leading to weight loss. Metabolic changes: Gabapentin may influence metabolic pathways, affecting how the body processes energy and stores fat. The cause of weight gain with gabapentin is likely due to increased appetite. You may be hungry more often. In some cases, weight gain may be due to fluid retention, another side effect of gabapentin. Another possible cause is not getting enough exercise if gabapentin is causing fatigue. Some ways to avoid weight gain include:
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