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All pregnant women in the UK will be offered a very detailed anomaly scan at around 20 weeks of pregnancy as part of their routine antenatal care. No extra monitoring for major birth defects is required following gabapentin use in pregnancy. Babies exposed to gabapentin before delivery may experience withdrawal symptoms for a few days after birth. Gabapentin may cause side effects such as dizziness, drowsiness, and dizziness. It is important to follow the prescribed dosage and seek medical attention if experiencing serious side effects or changes in mood or behavior. Gabapentin is prescribed by healthcare professionals and should only be taken under medical supervision. When treating neuropathic pain in a woman who is pregnant, the use of gabapentinoids (e.g. gabapentin) or an antiepileptic drug (AED) (e.g. levetiracetam, lamotrigine) is a last line option. This is due to the limited availability of data for safe use during pregnancy. Other options should be trialled first. Learn about gabapentin use in pregnancy and breastfeeding, including potential risks, benefits, and alternatives. Find out how gabapentin can affect fertility, miscarriage, birth defects, and baby development. Animal studies have shown that gabapentin intake during pregnancy increases the risk of embryo fetal toxicity, specifically on mice. For rats, adverse effects on offspring development were common among those who had gabapentin during pregnancy. Talk to your doctor about taking gabapentin if you are pregnant or are planning on being pregnant. A prospective study of 223 pregnancies exposed to gabapentin and 223 unexposed pregnancies found similar rates of major malformations, but higher rates of preterm births and low birth weight in the gabapentin group. The data are reassuring but still small and more research is needed to clarify the reproductive safety of this medication. Gabapentin is an antiepileptic drug used for various conditions, but its safety in pregnancy is unclear. A large study found no evidence of major malformations, but a slightly higher risk of cardiac defects and adverse outcomes. Gabapentin/first trimester of pregnancy: 10 newborns (0.01%) [30] Patorno et al., 2020: Gabapentin/first trimester of pregnancy: 4642 pregnancies (0.26%) Patorno et al., 2020: Gabapentin/early in pregnancy (first 140 days of pregnancy and no gabapentin dispensing from the 141 and 245 days)3745 pregnancies (0.21%) Patorno et al., 2020 Selected References: Blotiere PO, et al. 2020. Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. BMJ Open 10(6). Brannon GE, Rolland PD. Anorgasmia in a patient with bipolar disorder type 1 treated with gabapentin. J Clin Psychopharmacol. 2000;20(3):379 Our findings also suggest that pregnant women using gabapentin during pregnancy may be considered for targeted interventions to monitor for and promptly respond to the potential adverse outcomes associated with the use of this agent. Gabapentin is a γ-aminobutyric acid analog formally indicated for the treatment of epilepsy and neuropathic pain that is gaining increased popularity. Gabapentin has been historically considered a safe medication, including during pregnancy and lactation, with low reported concerns for misuse and us It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take gabapentin. We examined the risk of major congenital malformations and cardiac defects associated with gabapentin exposure during the first trimester (T1), and the risk of preeclampsia (PE), preterm birth (PTB), small for gestational age (SGA), and neonatal intensive care unit admission (NICUa) associated with gabapentin exposure early, late, or both early Gabapentin is not generally recommended in pregnancy as there is not enough information about its safety. It may cause withdrawal symptoms in newborn babies and should only be taken if the benefits outweigh the risks. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. More research is required to define the pregnancy safety profile of gabapentin. Pregnant women and women of childbearing potential should be made aware of the lack of data for most pregnancy outcomes. Gabapentin should only be used during pregnancy where benefits of treatment are considered to outweigh any potential risks. We have data on 223 pregnancy outcomes exposed to gabapentin and 223 unexposed pregnancies. The rates of major malformations were similar in both groups (p = 0.845). There was a higher rate of preterm births (p = 0.019) and low birth weight <2,500 g (p = 0.033) in the gabapentin group. Learn about the reproductive safety of gabapentin, a medication used for various conditions, based on a review of available data and a prospective study. The risk of major malformations is low, but there may be an increased risk of preterm births and low birth weight. Gabapentin is an antiepileptic drug that may cause birth defects and harm the fetus. Learn about the risks, benefits, and alternatives of using gabapentin during pregnancy and breastfeeding. Abstract Background. Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes.
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