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Purpose: The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (GBP) on sleep. This study is the first to systematically assess the clinical value of gabapentin for the treatment of sleep disorders. We found that regardless the type of sleep outcomes, gabapentin displayed stable treatment efficacy for sleep disturbance in patients with medical illness. Gabapentin has shown promise in treating insomnia in adults. The purpose of our study was to review our experience with using gabapentin to treat insomnia in children. We identified 23 children, seen by the authors in our Pediatric Sleep Clinic from January 2009 to March 2012. The mean age was 7.2 years and 70% were male. Preliminary evidence indicates that gabapentin can attenuate insomnia, bolster sleep quality, and increase total sleep duration. Moreover, gabapentin has been shown to increase slow-wave sleep (SWS), promote sleep maintenance, and decrease unwanted awakenings throughout the night. Some research suggests that gabapentin might alter the distribution of sleep stages throughout the night, potentially affecting the duration and quality of REM sleep. Research findings on gabapentin’s effects on REM sleep have yielded mixed results, highlighting the complexity of sleep pharmacology. On the contrary, gabapentin did not normalize sleep deprivation-induced disruption in sensorimotor gating. Conclusions: Sleep deprivation via modified multiple platform technique could be used as an animal model for psychosis. Gabapentin may have dose- and duration-dependent effects on sensorimotor gating and locomotor activity. REM sleep behavior disorder is linked to antidepressant use and may be an early indicator of Parkinson disease, Lewy body dementia, and multiple system atrophy because more than 90% of patients The sleep questionnaire included the average number of hours of sleep per night, sleep latency, number of awakenings and their cause, napping habits, caffeine use, and sleep disorder symptoms such as snoring, witnessed apnea, difficulty initiating or maintaining sleep, restlessness, and uncomfortable sensations in the legs in the evening According to a 2010 study, gabapentin can improve sleep quality and slow-wave sleep (deep sleep), lower your risk of spontaneous nighttime wake-ups, and prevent premature morning awakenings. Gabapentin is especially effective for those struggling with primary insomnia and slow-wave sleep disruptions. Gabapentin is often prescribed for individuals suffering from primary insomnia because it can improve sleep efficiency and reduce sleep disturbances. The medication works by interacting with a naturally occurring chemical known as gamma-aminobutyric acid (GABA). Some studies have found that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical restoration and cognitive function. Additionally, it may reduce sleep fragmentation, leading to fewer nighttime awakenings and improved sleep continuity. Gabapentin, an α 2 δ subunit ligand of L-type voltage-gated calcium channels, is indicated for the management of postherpetic neuralgia and restless legs syndrome, and as adjunctive therapy for partial seizures with and without secondary generalization (maximal dose: 600-1800 mg/day depending on indication and gabapentin formulation). 8 –10 Research suggests that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical recovery and memory consolidation. This effect could be particularly beneficial for individuals who struggle to achieve restorative sleep due to pain or anxiety. Results: Polysomnographic study revealed increased sleep efficiency and slow-wave sleep, decreased wake after sleep onset, and spontaneous arousal index after gabapentin treatment. The biochemical blood test revealed decreased prolactin levels in the morning after treatment. The Mechanism Behind Gabapentin’s Sleep-Inducing Effects. To comprehend how gabapentin works for sleep, it’s essential to delve into its mechanism of action in the brain. Gabapentin for Sleep: Effectiveness, Dosage, and Considerations explores this topic in depth, but let’s break it down further. Gabapentin primarily affects the normal subjects forms a convenient model for sleep disruption that could potentially be reversed by a drug with the properties of gabapentin. If effective, studies in other forms of sleep disruption would be appropriate. This study looks at the ability of gabap-entin to improve or reverse sleep disruption caused by alcohol consumption. METHODS Gabapentin is a medication commonly used to treat seizures, nerve pain, and other conditions. While it can be an effective treatment option for many patients, it's important to be aware of the potential side effects, including insomnia. What is Insomnia? Insomnia is a sleep disorder that can make it difficult to fall asleep, stay asleep, or both. Some research shows gabapentin may be effective for sleep. But it comes with risks, including dizziness, falls, and fluid buildup. Gabapentin is a controlled substance in some states. It can lead to dependence and misuse. It’s best to avoid taking gabapentin with other medications that cause drowsiness, like opioids and benzodiazepines. Most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. Two small studies showed that gabapentin may help people with primary insomnia and occasional sleep disturbance improve total sleep time and wakefulness in the morning. As reported in a small study that was published in the March-April 2010 edition of the journal Clinical Neuropharmacology, “Gabapentin enhances slow-wave sleep in patients with primary insomnia. It also improves sleep quality by elevating sleep efficiency and decreasing spontaneous arousal.”
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