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Topiramate has one huge advantage over many other psychotropics: it causes weight loss -not gain. While gabapentin caused an average gain of 2.2 kg during randomized trials (nearly as much as olanzapine’s 2.4 kg and worse than quetiapine’s 1.1 kg), topiramate caused an average loss of 3.8 kg. 3 Although the drug never lasted in clinical trials for weight loss, many doctors are knowledgeable that patients taking Topamax are likely to lose some weight. Below is a list of factors that may influence how Topamax works to promote weight loss. Notably, topiramate may contribute to weight loss by reducing calorie intake, decreasing fat gain, and lowering triglyceride and cholesterol levels. Additionally, its impact on reward pathways associated with food could play a role. Multiple clinical studies have supported the use of topiramate as a weight-loss medication. Weight loss is a well-known topiramate side effect. In fact, topiramate, combined with another medication called phentermine , is FDA approved for weight loss. It’s not clear how topiramate causes weight loss. But some research indicates it may lower your appetite, increase your metabolism, and reduce your desire for food. In studies, Topamax seems to be effective for weight loss and well-tolerated by most people. Unlike some other medications, Topamax’s weight-loss effect seems to continue past the 6-month mark. Higher doses of Topamax generally result in more weight loss but make side effects more likely. Compare Gabapentin vs Topamax head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Using gabapentin together with topiramate may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Topamax treats seizures by acting on calcium and sodium channels and GABA receptors, which help to lower the seizure threshold. These actions also help suppress your appetite, resulting in lower calorie intake, and make you feel more full by changing the way your body uses energy. Using gabapentin together with topiramate may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Gabapentin and topiramate have emerged as potential weight loss aids, but their effectiveness and safety require careful consideration․ Understanding their mechanisms, risks, and limitations is crucial before considering them․ I’m taking 25 mg with Phentermine specifically for weight loss. I’ve been on Phen for 4 weeks now and 3 weeks for Topiramate/Topamax. After 4 weeks I titrate to 50 mg. Dr wants to keep me at 50 mg if it keeps my appetite at bay. I’ve lost 15 lbs so far. After 12 weeks on Phen I need to stop that one but stay on Top. We would like to show you a description here but the site won’t allow us. In this guide you will learn how Topamax works for weight loss, why it may be effective, the side effects it can cause, what dose you need for it to work and other weight loss medications to compare it to. Consider calcium channel blockers, angiotensin-converting enzyme inhibitor (ACEIs), angiotensin receptor blockers (ARBs), and thiazide or loop diuretics, as indicated. *Weight gain and weight loss have been reported. In another RCT comparing the use of topiramate and gabapentin in migraine prophylaxis, both drugs were equally effective in migraine prophylaxis [157]. However, weight gain was a common side effect associated with gabapentin (7.5% of patients) while weight loss was linked to topiramate (22.5% of patients) [157]. Compare Gabapentin vs Topiramate head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Weight loss (10.9%) Brain fog (8.9%) Loss Topamax isn’t approved for weight loss. However, the drug may reduce your appetite, which may lead you to lose weight. In clinical trials, weight loss occurred in 6% to 17% of people who took Topamax (topiramate) is a medication that treats seizures and prevents migraines. It’s also sometimes taken off-label for depression, weight loss, nerve pain, and more. Topamax comes in a variety of formulations, including a generic form called topiramate. It’s available as tablets, sprinkle capsules, and extended-release (ER) capsules.
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