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Lifestyle modifications should be the first-line approach for women with menopausal symptoms. Nonapproved alternative agents include venlafaxine, fluoxetine, paroxetine, gabapentin, soy products, and herbs such as black cohosh. Do not start taking venlafaxine during the 14 days after you stop a MAO inhibitor and wait 7 days after stopping venlafaxine before you start taking a MAO inhibitor. If you take them together or do not wait the proper amount of time, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body Venlafaxine has been used off label for the treatment of diabetic neuropathy [16] and migraine prevention. [17] It may work on pain via effects on the opioid receptor. [18] It has also been found to reduce the severity of 'hot flashes' in menopausal women and men on hormonal therapy for the treatment of prostate cancer. [19] [20] Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Venlafaxine is not FDA approved for use in children. Before taking this medicine. You should not take venlafaxine if you are allergic to it or to desvenlafaxine . Do not use venlafaxine if you have used an MAO inhibitor in the past 14 days. What non-hormonal medicines are used to reduce hot flushes? The non-hormonal medicines used to reduce hot flushes in women include gabapentin, clonidine, venlafaxine or selective serotonin reuptake inhibitors (SSRIs). The treatment option depends on the individual. Brand name: Neurontin® available as 100mg, 300mg, 400mg, 600mg and 800mg capsules. The patients who were taking venlafaxine started with fewer hot flashes at baseline (mean hot flash score of 11.5 vs 20.7 per day, mean hot flash frequency of 7.1 vs 10.5 per day). By week 5, these 5 patients had a greater hot flash reduction from baseline (hot flash scores of 24% vs 33% of baseline, hot flash frequencies of 28% vs 37% of Gabapentin (Neurontin, Gralise, others). This antiseizure medicine helps ease hot flashes. Side effects can include being drowsy, dizzy or tired and swelling in the arms and legs, called edema. Pregabalin (Lyrica). This is another anti-seizure medicine that can help ease hot flashes. The most effective nonestrogenic agents for treating hot flashes, studied to date, are progesterone analogs. Low doses of megestrol acetate (20-40 mg orally/d) or medroxyprogesterone acetate (400-500 mg intramuscularly as a single dose, that can be repeated months later if effects wear off) decrease hot flashes to a similar degree to what is seen with estrogen. 20,22,31,32 Clinically, these Hot flashes happen in about 80% of menopausal women and on average, last for more than seven years. Though some women continue to experience them longer than 10 years. Dr. Kling says that treating hot flashes and having another option to help women during these years creates a ripple effect. Its effectiveness in treating hot flashes was discovered serendipitously during trials for other conditions, further expanding its therapeutic scope. How Gabapentin Helps with Hot Flashes. Gabapentin has shown promising results in reducing both the frequency and severity of hot flashes. We undertook a randomised, double-blind, placebo-controlled, multi-institutional trial to assess the efficacy of gabapentin in controlling hot flashes in women with breast cancer. Pandya KJ, Morrow GR, Roscoe JA, et al. Gabapentin for hot flashes in 420 women with breast cancer: a randomized double blind placebo-controlled trial. Lancet 2005; 366:818–24. DOI 10.1016/S0140-6736(05)67215-7 Furthermore‚ venlafaxine is sometimes used off-label to manage hot flashes in menopausal women‚ as well as to treat nerve pain associated with conditions like fibromyalgia or diabetic neuropathy. Clonidine, venlafaxine, paroxetine, fluoxetine, and gabapentin are nonhormonal agents that have demonstrated efficacy in small controlled and uncontrolled trials in reducing hot flashes and should be considered in patients unwilling or unable to take hormonal therapies. This individual patient pooled analysis supports that newer antidepressants and gabapentin decrease hot flashes. With regard to the newer antidepressants, it seems that venlafaxine and paroxetine are more effective than the studied doses of sertraline and fluoxetine. Venlafaxine oral tablet is a prescription drug used to treat depression and social anxiety disorder (SAD). It comes in two forms: immediate-release (treats depression) and extended-release (treats Selective serotonin reuptake inhibitors and venlafaxine have been shown to reduce hot flashes by 19 to 60 percent and were well tolerated by study participants. Soy isoflavones reduced Venlafaxine is available as Effexor XR and generic venlafaxine in the following dosage forms that are taken by mouth. 37.5 mg, 75 mg, 150 mg extended-release oral capsules Several clinical studies have shown that gabapentin becomes effective at reducing hot flashes within around 4 weeks of taking it consistently. And while some may feel a benefit sooner when using an SSRI or venlafaxine to treat hot flashes, it is prudent to initiate the medication at a low dosage and titrate to effect. clonidine SUmmARy
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