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There are 145 drugs known to interact with Vimpat (lacosamide), along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 11 are major, 127 are moderate, and 7 are minor. Recently, other AEDs, such as eslicarbazepine, sodium valproate, lamotrigine, levetiracetam and gabapentin have also been reported to cause hyponatremia. Understanding the risk associated with AED-induced hyponatremia and taking effective measures to combat serum sodium imbalance induced by AED therapy are necessary. Donato Di Paola et al. (2007) used a very similar experimental design in the audiogenic seizure model and reported synergistic interactions of levetiracetam with felbamate, gabapentin, and topiramate (see Table 2). When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another Gabapentin is in the drug class gamma-aminobutyric acid analogs. A total of 145 drugs are known to interact with Vimpat. Vimpat is in the drug class miscellaneous anticonvulsants. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Compare Gabapentin vs Vimpat head-to-head with other drugs for uses, ratings, cost, side effects and interactions. More patients appear to continue with topiramate compared with lamotrigine or gabapentin, possibly because of better perceived efficacy of topiramate, despite its having the highest incidence of adverse effects. This is followed by lamotrigine (29%) and gabapentin (< 10%) [13, 69, 70]. These studies have not revealed any particularly Keppra Interactions. There are 238 drugs known to interact with Keppra (levetiracetam), along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 6 are major, 229 are moderate, and 3 are minor. Find a comprehensive list of seizure medications, including brand name & generic medicines. Each medication for epilepsy has different uses & side effects. Gabapentin, oxcarbazepine, and lamotrigine possess randomized controlled trial evidence for monotherapy treatment of partial-onset seizures and topiramate has evidence for monotherapy use in new onset epilepsy [3, 4]. Methods: The anticonvulsant effect of LCM in combination with other AEDs including carbamazepine (CBZ), phenytoin (PHT), valproate (VPA), lamotrigine (LTG), topiramate (TPM), gabapentin (GBP), and levetiracetam (LEV) at fixed dose ratios of 1:3, 1:1, and 3:1, was evaluated in the 6-Hz-induced seizure model in mice. In addition, the impact of Levetiracetam, gabapentin and pregabalin have not been reported to cause or be a target for clinically relevant pharmacokinetic drug interactions. Pharmacodynamic interactions involving AEDs have not been well characterized, but their understanding is important for a more rational approach to combination therapy. The phase IV clinical study analyzes what interactions people have when they take Vimpat and Gabapentin, and groups them by gender, age and more. It is created by eHealthMe based on reports of 798 people who take the same drugs from the FDA, and is updated regularly. Lacosamide was approved for use as an anticonvulsant in the United States in 2011 and current indications are for its use in partial-onset seizures in patients 4 years of age or above either alone or in combination with other anti-epileptic agents. Lacosamide is available in tablets of 50, 100, 150 and 200 mg under the brand name Vimpat. We compare the side effects and drug effectiveness of Vimpat and Gabapentin. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 462,969 people who take Vimpat and Gabapentin, and is updated regularly. Gabapentin extended-release tablets (Horizant) are used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Gabapentin is in a class of medications called anticonvulsants. Hyponatremia is an adverse effect of some antiepileptic drugs (AEDs) and has been especially reported under oxcarbazepine (OXC) and carbamazepine (CBZ) (Dong et al., 2005; Lu and Wang, 2017). Usually, a single medication can help people with epilepsy keep their seizures under control. But if one medication is only partially effective for you, your doctor may sometimes add another drug. Or your doctor may choose to combine your medication with surgery, an implanted device, or a special diet. Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. Gabapentin (Neurontin®) GBP Lacosamide (Vimpat®) LCM LamoTRIgine (Lamictal®) LTG LevETIRAcetam (Keppra®) LEV LORazepam (Ativan®) LZP ClonazePAM (Klonopin®) CZP Clorazepate (Tranxene®) CLZ DiazePAM (Valium®) DZP Eslicarbazapine (Aptiom®) ESL NO Anti-Epileptic Drug (AED) Substitution Guidance Document for Patients Unable to Take Oral
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