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Our results show that the GBP plus vitamins B1-B12 combination is as effective as PGB for pain treatment. Pain intensity reduction was achieved with a 300 to 1800 mg/day dose of GBP/B1/B12 and in the same proportion as PGB 600 mg (maximum dose). gabapentin and vitamin B12 combination group has better average pain relief compared to the gabapentin monotherapy group. Table 5 shows that there is a significant difference in pain A very recent study shows that gabapentin plus the B1/B12 combination is as effective as gabapentin by itself. Moreover, the combination therapy reduced pain intensity with a gabapentin dose at 50% of the minimum dose required when gabapentin was used alone (800 vs. 1600 mg/day). Gabapentin+Methylcobalamin is a combination medicine. It is used to treat neuro. pathic pain, a condition of abnormal painful sensation in different body parts due to damage in a part of the brain responsible for sensing the external stimuli. Gabapentin+Methylcobalamin is available in the form of tablet, capsule. Our study shows that GPB/B1-B12 combination is as effective as PGB. Nonetheless, pain intensity reduction is achieved with 50% of the minimum required gabapentin dose alone (800 to 1600 mg/d) in classic NDD trials. DOI: 10.29313/GMHC.V8I1.3676 Corpus ID: 219009566; Combination of Gabapentin and Vitamin B12 Compared with Gabapentin Monotherapy on Pain Improvement of Diabetic Neuropathy Patients Gabapentin is in the drug class gamma-aminobutyric acid analogs. A total of 15 drugs are known to interact with Vitamin B12. Vitamin b12 is in the drug class vitamins. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Gabapentin+Methylcobalamin is a combination of two medicines: Gabapentin and Methylcobalamin. This medication is useful in the treatment of pain due to nerve damage (peripheral neuropathy). This medication works by regenerating damaged nerves in the body and decreasing the pain sensation. The primary treatment of diabetic neuropathy pain in Indonesia is gabapentin and vitamin B12. The study aimed to compare pain improvements in diabetic neuropathy patients. The drug used was a combination of gabapentin and vitamin B12 and gabapentin monotherapy. For the pain degree measurement, we used the visual analogue scale (VAS). Mochamad Firdaus Bhuanaputra et al.: Combination of Gabapentin and Vitamin B12 Compared with Gabapentin Table 1 Average Result of VAS Score Check in the Gabapentin and Vitamin B12 Combination Group VAS Score Gabapentin and Vitamin B12 Combination Group Average (SD) Median (Min–Max) VAS 0 week 7.45 (0.50) 7 (7–8) VAS 4th week 7.36 (0.49) 7 Combination showed efficacy to reduce the intensity of pain and improved quality of life. Conclusions: This study showed that combination of gabapentin plus vitamins B 1 and B 12 reduce neuropathic pain and improve the quality of life with an excellent safety profile. The gabapentin and vitamin B12 combination group has better average pain relief compared to the gabapentin monotherapy group. Table 5 shows that there is a significant difference in pain relief between gabapentin and vitamin B12 combination group and gabapentin monotherapy (p value<0.002). There have been a few studies in the literature looking at combination therapy with gabapentin and pregabalin [18, 19]. Although as discussed earlier, this would require careful monitoring and oversight from healthcare providers so that the combined CNS depression from both medications does not lead to serious consequences of gait leading to This study concluded that gabapentin and vitamin B12 combination is better in improving pain in diabetic neuropathy patients compared to gabapentin monotherapy. This study concluded that gabapentin and vitamin B12 combination is better in improving pain in diabetic neuropathy patients compared to gabapentin monotherapy. Gabapentin+mecobalamin is a combination of two medicines: Gabapentin (anti-convulsant), Mecobalamin (vitamin B12). Gabapentin treats seizures by balancing a chemical messenger in the brain called a neurotransmitter, thereby decreasing its abnormal excitement in the brain. Gabantin Plus Tablet is a combination of two medicines: Gabapentin and Methylcobalamin. This medication is useful in the treatment of pain due to nerve damage (peripheral neuropathy). This medication works by regenerating damaged nerves in the body and decreasing the pain sensation. We designed this study to compare the effect of combined vitamin B complex—gabapentin versus gabapentin alone on postoperative pain in women undergoing cesarean section under spinal anesthesia. Early in vitro studies evaluating the pharmacological combination of KLS and gabapentin (i.e., single agents in a mixture) provided initial proof-of-concept evidence that coadministration with KLS can improve gabapentin’s analgesic effects by enhancing its inhibition of PKC𝜀 translocation on the membrane of sensory neurons [130,155]. Our study shows that GPB/B1-B12 combination is as effective as PGB. Nonetheless, pain intensity reduction is achieved with 50% of the minimum required gabapentin dose alone (800 to 1600 mg/d)
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