Drug FDA pregnancy category* AAP rating Lactation risk category†; Anxiolytics and hypnotics: Benzodiazepines: Alprazolam (Xanax) D: Unknown, of concern: L3: Chlordiazepoxide (Librium) The LactMed® database contains information on drugs and other chemicals to which breastfeeding mothers may be exposed. It includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant. category หมายเหตุ อาการผิดปกติที่เกิดกับทารกในครรภ (Fetal / Neonatal effects) Lactation Acetylcysteine B ไม มีการศึกษาการใช ยาในหญิงมีครรภ , (inj.)Inadequate human studies but reported safety The U.S. Food and Drug Administration classifies gabapentin (Neurontin) as a Pregnancy Category C medication, which means that animal studies conducted on this medication has caused harm on the fetus. Breastfeeding while taking gabapentin: Gabapentin enters breastmilk in low levels. Blood tests on breastfed infants found low levels or levels too low to be detected. There are reports of infants exposed to gabapentin through breastmilk; no side effects were noted. gabapentin is considered compatible with breastfeeding, but should be used with caution and infant monitoring (1) published evidence for the use of gabapentin during breastfeeding is very limited. Data is from 10 mothers using gabapentin doses up to 2.1g daily Kaufman KR, Struck PJ. Gabapentin-induced sexual dysfunction. Epilepsy Behav. 2011;21(3):324-6. Kristensen JH, Ilett KF, Hackett LP, et al. Gabapentin and breastfeeding: A case report. J Hum Lact. 2006;22:426–8. Loudin, S, et al. (2017). An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids. Gabapentinand breastfeeding. gabapentin is considered compatible with breastfeeding, but should be used with caution and infant monitoring (1) published evidence for the use of gabapentin during breastfeeding is very limited. Data is from 10 mothers using gabapentin doses up to 2.1g daily With maternal doses up to 2.1 g/day, estimated doses for fully breastfed infants are 0.2 to 1.3 mg/kg/day (equivalent to 1.3 to 3.8% of the maternal weight-adjusted dose). An expert panel has deemed this drug is an acceptable choice for refractory restless leg syndrome during lactation. Gabapentin is a γ-aminobutyric acid analog formally indicated for the treatment of epilepsy and neuropathic pain that is gaining increased popularity. Gabapentin has been historically considered a safe medication, including during pregnancy and lactation, with low reported concerns for misuse and us Pregnancy category C, safety unknown in breastfeeding. $55 ($145) Opioids may increase levels of gabapentin. Pregnancy category C, limited data that it is safe in breastfeeding. Three infants who were 2 to 3 weeks of age and one who was 14 weeks of age were breastfed during maternal use of gabapentin in an average daily dosages of 1575 mg (range 600 mg to 2.1 grams daily). Serum levels were measured after the morning nursing before the mothers' morning dose of gabapentin (10 to 15 hours after the prior evening's dose). Results: The literature review produced 183 original articles for evaluation, which revealed data for 62 of the 96 psychotropic drugs. The remaining 34 medications had no data (including from the Gabapentin is considered compatible with breastfeeding, but should be used with caution and infant monitoring. Published evidence for the use of gabapentin during breastfeeding is very limited. Data is from 10 mothers using gabapentin doses up to 2.1g daily. The aim of this study was to describe the milk-plasma ratio and relative infant dose of gabapentin in a breastfeeding mother and to determine the well-being of her exposed infant. The mother-infant pair was studied over a 24-hour dose interval at steady state. Gabapentin concentrations were quantifi If your doctor or health visitor says your baby is healthy, you can take gabapentin while breastfeeding. It's important to keep taking gabapentin to keep you well. Gabapentin passes into breast milk in small amounts. It has not been known to cause any side effects in breastfed babies. Breastfeeding while taking gabapentin: Gabapentin enters breastmilk in low levels. Blood tests on breastfed infants found low levels or levels too low to be detected. There are reports of infants exposed to gabapentin through breastmilk; no side effects were noted. Maternal doses of gabapentin up to 2.1 g/day produce relatively low levels in infant serum. A single oral dose of either 300 or 600 mg given to the mother before cesarean section appeared to have no effect on breastfeeding initiation. Therefore, gabapentin, lamotrigine, oxcarbazepine, vigabatrin, tiagabine, pregabalin, leviracetam and topiramate are compatible with breastfeeding with a less documented safety profile. Ethosuximide, zonisamide and the continue use of clonazepam and diazepam are contraindicated during breastfeeding. A single oral dose of either 300 mg or 600 mg given to the mother before cesarean section appeared to have no effect on breastfeeding initiation. An expert consensus guideline indicates that gabapentin is an acceptable choice for refractory restless leg syndrome during lactation.
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