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The LactMed® database contains information on drugs and other chemicals to which breastfeeding mothers may be exposed. It includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant. Assuming a daily milk intake of 150 mL/day/kg, the infant dose of gabapentin was estimated to be 0.2-1.3 mg/kg/day, which is equivalent to 1.3-3.8% of the weight-normalized dose received by the mother. The plasma levels of gabapentin collected after 3 months of breastfeeding in another infant was 1.9 µM. Another prospective study in Norway followed infants of mothers who took antiepileptic drugs during pregnancy and lactation. These infants were compared with control groups of infants of mothers with untreated epilepsy and infants with fathers who took antiepileptics. 3 Infants were assessed at 6, 18, and 36 months of age. Although some Breastfeeding while taking gabapentin: Gabapentin enters breastmilk in low levels. Blood tests on breastfed infants found low levels or levels too low to be detected. There are reports of infants exposed to gabapentin through breastmilk; no side effects were noted. The InfantRisk Center is dedicated to supporting the health of mothers and infants at the intersection of maternal medicine and breastfeeding. We support the WHO Code’s principles and our shared goal of fostering safe and healthy infant feeding practices that best serve both mothers and their children. I would recommend you continue to take the lorazepam instead of switching. Your infant is accustomed to metabolizing this medication already. Just remember that when you decide to stop breastfeeding to wean your infant slowly so there are no withdrawal symptoms, or if you decide to stop taking the medication wean slowly also. Sandra Lovato R.N. The aim of this study was to describe the milk-plasma ratio and relative infant dose of gabapentin in a breastfeeding mother and to determine the well-being of her exposed infant. The mother-infant pair was studied over a 24-hour dose interval at steady state. Gabapentin concentrations were quantifi Gabapentin Breastfeeding Warnings. Benefits should clearly outweigh risks Excreted into human milk: Yes Comments:-Breastfed infants should be monitored for drowsiness, adequate weight gain, and developmental milestones, especially when used in combination with other anticonvulsant or psychotropic drugs and in younger, exclusively breastfed infants. Keywords: Antiepileptic drugs, Breastfeeding, Lactation risk. Introduction. Breastfeeding is known for its beneficial effects on both mothers and infants [1,2]. Nevertheless, in mothers suffering from epilepsy or bipolar disorders treated with antiepileptic drugs (AEDs), some concerns on infant health may raise. Gabapentin or pregabalin are compatible with breastfeeding, but should be used with caution and infant monitoring. They have low levels in breast milk and infant serum, and no adverse effects have been reported. Does taking gabapentin increase the chance of birth defects? Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Heroin should be avoided due to infant risks as well as the increased risk of infectious diseases such as HIV. Talk with your healthcare professional about opioid use while breastfeeding. Medicines used to treat opioid use disorder The ultimate decision to breastfeed while taking medications should be based on an informed decision including available data, discussions between a mother, her physician, and the infants' pediatrician. The decision to take medications during pregnancy should be based available data and a discussion between a mother and her OB/GYN. If your doctor or health visitor says your baby is healthy, you can take gabapentin while breastfeeding. It's important to keep taking gabapentin to keep you well. Gabapentin passes into breast milk in small amounts. An infant whose mother was taking gabapentin 36.7 mg/kg daily breastfed her infant 6 to 7 times daily with some additional artificial feeding at night. At 1.6 months of age, the infant's plasma gabapentin concentration was 0.4 mg/L which was about 6% of the average maternal plasma concentration. Can Breastfeeding Women Take Gabapentin? Gabapentin is excreted into the breast milk in women. It is believed that the nursing infant may be exposed to a maximum dose of approximately 1 mg/kg per day of gabapentin. We think it is probably ok to breastfeed if your dose is within or below the normal dose range of 300mg-600mg 3 times a day and your infant is not symptomatic. Monitor your infant for sedation or irritability, not waking to feed/poor feeding, vomiting and tremor. Gabapentin is an anticonvulsant drug that may be used during lactation. It has low levels in infant serum and no reported adverse effects, but monitor the infant for drowsiness and developmental milestones. Background: The benefits of breastfeeding for both mother and infant are well documented. The World Health Organization recommends exclusive breastfeeding for the first four to six months of life Breastfeeding while taking gabapentin: Gabapentin enters breastmilk in low levels. Blood tests on breastfed infants found low levels or levels too low to be detected. There are reports of infants exposed to gabapentin through breastmilk; no side effects were noted.
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