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In cats, gabapentin is most often used as a pain medication for chronic pain, such as from arthritis. Gabapentin is also recognized as beneficial in reducing the fear responses that a kitty may have to the stress of handling and being examined at the vet. Abstract OBJECTIVE To determine the effects of oral gabapentin administration prior to veterinary examination on signs of stress in cats. DESIGN Randomized, blinded, crossover clinical trial. ANIMALS 20 healthy pet cats with a history of fractious behavior or signs of stress during veterinary examination. PROCEDURES Cats were scheduled for 2 veterinary visits 1 week apart and randomly assigned Results of this study suggested that gabapentin is a safe and effective treatment for cats to help reduce stress and aggression and increase compliance for transportation and veterinary examination. This study set out to investigate the effect of giving a single dose of gabapentin for fear-based aggressive behaviors in cats during veterinary visits. The researchers compared a dose of either 100 or 200 mg/cat to placebo capsules 2 hours prior to the vet visit. Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. J Am Vet Med Assoc. 2017 Nov 15;251(10):1175-1181. Stress associated with transportation, examination, and diagnostic procedures is a major barrier that often prevents pet cats from receiving regular veterinary care. Cats can suffer from severe fear and stress when being transported to the veterinarian or while being examined once there. New research indicates that use of the medication gabapentin can significantly reduce signs of stress and increase compliance with the veterinary exam. Gabapentin for cats is a safe and effective drug used to treat conditions that cause chronic pain, stress and anxiety. Learn more about this drug, the benefits of using it and how it can benefit your cat. Per-protocol analysis showed that gabapentin predicted quicker behavior modification progression and lower cat stress score, latency to emerge, and urine suppression compared to placebo. Median time to graduation was reduced by half with gabapentin. Gabapentin (50 or 100 mg, PO) is important in attenuating stress and fear responses in client-owned and cage-trap community cats undergoing transportation and veterinary consultation, and remains a valuable component of a holistic approach to feline pain management. 60,165 There is moderate to good evidence to indicate that a single dose (100 mg) of oral gabapentin administered to cats might reduce signs of acute stress associated with veterinary visits. Two blinded, randomised, placebo controlled trials were reviewed, with consistency of direction of effect for the main outcome measure (Cat Stress Score) assessed. Gabapentin and pregabalin The anxiolytic effect of gabapentin and pregabalin is believed to be mediated by the binding of voltage-sensitive calcium channels in the amygdala, preventing the release of the excitatory neurotransmitter glutamate and the associated fear response. 49 Peak levels occur about 100 mins after dosing in cats and Another study evaluated the benefit of gabapentin to reduce stress in a trap, neuter, and return programme. 5 These authors also used a wide dose range of 9-47 mg/kg because of the use of a set size capsule across a range of cat sizes. They noted the greatest effect was at two hours post-administration.
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