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Median change in BP attributed to gabapentin was −12 mm Hg (range, −95 to 10 mm Hg) in healthy cats and −12 mm Hg (range, −43 to 21 mm Hg) in cats with CKD. Mean age differed in healthy cats (6.7 years) and cats with CKD (12 years), but minimal data are available to suggest this difference contributed substantially to the study results. Gabapentin (12.5 mg/kg PO q12h) was administered. Gabapentin is used in humans with neuropathic pain and is widely used in dogs and cats to treat chronic pain despite the lack of large clinical studies. Some case reports support its use in cats with chronic musculoskeletal disease. 12,13 Gabapentin is renally excreted. In cats, gabapentin is most often used as a pain medication for chronic pain, such as from arthritis. Gabapentin is also recognized as beneficial in reducing the fear responses that a kitty may have to the stress of handling and being examined at the vet. The Chill Protocol (ie, combination drug protocol that includes gabapentin, melatonin, and oral transmucosal acepromazine) is an option for preclinic sedation developed at the Cummings School of Veterinary Medicine at Tufts University to manage fearful and aggressive dogs and cats. 11 Dose-dependent sedation is a common adverse effect of A survey of clinicians found that gabapentin use in veterinary medicine is similar to use in human medicine; 69% of respondents indicated they prescribe gabapentin on a daily or weekly basis, most commonly for acute and chronic pain (extra-label). Gabapentin is widely used in cats to decrease fear and stress and treat some painful conditions (eg, osteoarthritis). Oral administration can be difficult in cats and can lead to treatment failure; less invasive administration methods are thus desirable. The Takeaways. Key pearls to put into practice: Gabapentin (20 mg/kg PO) given to healthy and hyperthyroid cats one hour prior to arrival at the clinic may significantly reduce stress and increase compliance with handling and examination. Affected cats have systemic disease rather than a lower urinary tract disorder, similar to humans with interstitial cystitis/bladder pain syndrome. 1,2 Stress is a key contributing factor of FIC, 2,3 and cats often have one or more comorbidities (ie, Pandora syndrome). 1,4 FIC usually self-resolves; however, outcomes may be extreme (eg, owner DRUGS & THERAPEUTICS Corticosteroids/Topicals/Dermatology Peer Reviewed Gabapentin CORRECT RESPONSE | Gabapentin is an anxiolytic often used in cats to decrease stress during veterinary visits, travel, and acclimation to a new household and can be used for neuropathic discomfort. 17,18 Stress levels in allergic cats can increase due to In cats, single-dose gabapentin (50-100 mg/cat) may result in decreased stress, but not necessarily sedation, 2 to 3 hours after oral administration. Gabapentin may be safely administered before anesthesia and routine surgery in healthy patients older than 4 months. In this episode, host Alyssa Watson, DVM, is joined by Rebecca Reader, DVM, DACVAA, to talk about her recent Clinician’s Brief article, “Top 5 Uses for Gabapentin in Dogs & Cats.” Dr. Reader sorts through the evidence to help us differentiate between all the ways gabapentin can be used and all the ways it should be used, which are far fewer. In the Literature. Pankratz KE, Ferris KK, Griffith EH, Sherman BL. Use of single-dose oral gabapentin to attenuate fear responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial. Adverse Effects of Pregabalin. Adverse effects were uncommon (<5% of cats) in pre-approval studies. Reported adverse effects may include ataxia, lethargy, emesis, anorexia, weight loss, tremor, and proprioceptive abnormality. 1 Sedation may occur but typically resolves within 6 hours after administration. Gabapentin is often used in dogs and cats to prevent seizures and treat neuropathic pain. Although gabapentin is a structural analog of the neurotransmitter gamma-aminobutyric acid (GABA), it appears not to interact with GABA receptors. Gabapentin is excreted unchanged in humans but is metabolized to N-methyl-gabapentin in dogs. Trusted content. Slovak JE, Costa AP. A pilot study of transdermal gabapentin in cats. J Vet Intern Med. 2021;35(4):1981-1987. Oral gabapentin in cats – often without additional sedation/premedication – can be used by house-call and clinic-bound veterinarians to facilitate examination, blood draws, cystocentesis and additional injections. Gabapentin’s popularity among veterinary patients is growing. Review the top 5 appropriate and inappropriate uses of gabapentin for dogs and cats in this guide. Get more clinical guidance with Standards of Care™ From the team that brings you Clinician’s Brief, extend your knowledge with expert-written, peer-reviewed diagnostic and treatment guidance as well as pet owner education and all the reliable drug information you love in Plumb’s. The Chill Protocol (ie, combination drug protocol that includes gabapentin, melatonin, and oral transmucosal acepromazine) is an option for preclinic sedation developed at the Cummings School of Veterinary Medicine at Tufts University to manage fearful and aggressive dogs and cats. 11 Dose-dependent sedation is a common adverse effect of In this episode, host Alyssa Watson, DVM, is joined by Rebecca Reader, DVM, DACVAA, to talk about her recent Clinician’s Brief article, “Top 5 Uses for Gabapentin in Dogs & Cats.” Dr. Reader sorts through the evidence to help us differentiate between all the ways gabapentin can be used and all the ways it should be used, which are far fewer.
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