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Best documented drugs for preventive treatment of cluster headache are verapamil and lithium, and possibly effective drugs are gabapentin, topiramate, divalproex sodium, and melatonin. The efficacy of monoclonal antibodies to the calcitonin gene-related peptide so far has been only demonstrated for episodic cluster headache. Cluster headache causes severe unilateral temporal or periorbital pain, lasting 15 to 180 minutes and accompanied by autonomic symptoms in the nose, eyes, and face. Gabapentin (Neurontin) may In an open-label study of 33 cluster headache patients (23 episodic cluster headache, 10 chronic cluster headache), 21% had a reduction of more than 50% in headache fre-quency during the 20-day study period. The response was not dose related (40). Side effects are reported in about 40% of studied cases: Cluster headaches are severely painful headaches that can affect a person several times a day. They may last for long periods at a time, called chronic cluster headaches, or for shorter periods of Gabapentin has a wide range of off-label applications, including as a treatment option for neuropathic pain, migraine prevention, and headaches, including tension and cluster types. In a study reviewing the available data and articles on the subject, gabapentin was found to have benefits for the majority of primary headache symptoms, including Gabapentin has recently been reported to be efficacious in the treatment of CCH. To test the potential of gabapentin as second-line drug, we prospectively studied the efficacy of gabapentin as add-on drug in eight patients suffering from CCH refractory to first-line treatment. Gabapentin was effective in the treatment of a patient with cluster headache. Further investigation of gabapentin compared with conventional treatments and placebo is warranted. Chronic cluster headache: Spira PJ, Beran RG Australian Gabapentin Chronic Daily Headache Group. Gabapentin in the prophylaxis of chronic daily headache: a randomized, placebo-controlled study Chronic cluster headache (CCH) is a rare but challenging condition. About 20% of CCH patients get refractory to treatment. Gabapentin has recently been reported to be efficacious in the treatment of CCH. Vlasta Vukovtcet al Gabapentin in the prophylaxis of cluster headache: an observational open label study especially gabapentin, as a prophylactic treatment in patients with cluster headache. We describe the use of gabapentin in the treatment and prophylaxis of cluster headache in a patient who was refractory to other treatments. Case Report A 38-year-old man had a history of intermittent right-side headaches for 24 years, diagnosed as cluster headache. Best documented drugs for preventive treatment of cluster headache are verapamil and lithium, and possibly effective drugs are gabapentin, topiramate, divalproex sodium, and melatonin. The efficacy of monoclonal antibodies to the calcitonin gene-related peptide so far has been only demonstrated for episodic cluster headache. Prompted by the results of gabaergic drugs, such as valproate and topiramate, we performed this pilot study to assess the effect of gabapentin in cluster headache. Eight patients suffering from episodic cluster headache and four suffering from chronic cluster headache were studied. Gabapentin (GBP), originally an antiepileptic drug, is more commonly used in the treatment of pain, including headache disorders. Off-label GBP is used in headache disorders with some success, some failure, and much debate. Best documented drugs for preventive treatment of cluster headache are verapamil and lithium, and possibly effective drugs are gabapentin, topiramate, divalproex sodium, and melatonin. The efficacy of monoclonal antibodies to the calcitonin gene-related peptide so far has been only demonstrated for episodic cluster headache. Cluster headache and trigeminal neuralgia are relatively rare but debilitating neurologic conditions. Although they are clinically and diagnostically distinct from migraine, many of the same pharmacologic agents are used in their management. For many patients, the attacks are so frequent and severe Prompted by the results of gabaergic drugs, such as valproate and topiramate, we performed this pilot study to assess the effect of gabapentin in cluster headache. Eight patients suffering from episodic cluster headache and four suffering from chronic cluster headache were studied. Keywords: cluster headache, treatment, clinical trials, drugs, neuromodulation. Introduction. Cluster headache (CH) is one of the most common primary headaches affecting 0.1% of the population . Unfortunately, an average delay of the diagnosis of CH is reported to be 5 years, and a minority of the patients do not receive adequate treatment These include topiramate (100–200 mg), gabapentin (900–3600 mg) and baclofen (30–60 mg).[40,41] Although methysergide was used widely by specialists and known to be effective for the preventive treatment of cluster headache, it is no longer manufactured and available for use. These include topiramate (100–200 mg), gabapentin (900–3600 mg) and baclofen (30–60 mg).[40,41] Although methysergide was used widely by specialists and known to be effective for the preventive treatment of cluster headache, it is no longer manufactured and available for use.
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