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Conclusion: Patients treated with gabapentin or pregabalin had an increased risk of dementia. Therefore, these drugs should be used with caution, particularly in susceptible individuals. Keywords: dementia, Alzheimer disease, cognitive impairment, gabapentin (GBP), pregabalin (PGB) A chi-square test analyzed categorical variables, while the Student's t-test assessed continuous variables when comparing dementia and non-dementia groups, including differences in the distribution of gabapentin use, age, sex, hypertension, hyperlipidemia, chronic liver disease, chronic kidney disease diabetes, malignancy, chronic obstructive Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., cognitive decline, functional status decline, and motor function change) in older adults. (See "Treatment of Alzheimer disease" and "Frontotemporal dementia: Treatment" and "Prognosis and treatment of dementia with Lewy bodies" and "Treatment of vascular cognitive impairment and dementia" and "Management of the patient with dementia" and "Care of patients with advanced dementia".) SYMPTOM ASSESSMENT We present the case of a patient with incipient vascular dementia accompanied by nocturnal agitation, which was successfully treated with gabapentin. Gabapentin appears to be useful and well-tolerated in this indication. The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood. Behavioral and Psychiatric Symptoms of Dementia (BPSD) increase patient mortality, healthcare costs and caregiver burnout. While behavioral interventions are the most effective treatment for BPSD, many patients are not able to regulate their agitation using only behavioral interventions, and therefore require pharmacotherapy. Gabapentin is used to help control partial seizures (convulsions) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. Gabapentin is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral Roane et al. reported three cases in which higher doses of gabapentin were used for the treatment of agitation in AD and one case of mixed dementia. The average dose of gabapentin in this study was 2400 mg day −1. dementia patient was only followed for three weeks. Next, it is unclear whether gabapentin is equally efficacious in Alzheimer’s dementia versus concomitant Alzheimer’s and vascular dementia. Additionally, the age difference of 17?years may have also contributed to the 97-year old’s limited response to gabapentin. 3.2 Functional status decline. The same sample was used for assessing functional status change as measuring cognitive decline ().At the first visit after index, the association of gabapentin initiation with functional decline was not significant for either change in FAQ sum (OR [95% CI]: 1.50 [0.76, 2.96]) or FAQ mean (1.56 [0.93, 2.63]). We would like to show you a description here but the site won’t allow us. Gabapentin has been administered to several geriatric patients with bipolar disorder and patients with dementia. It has also been reported to be successful in the treatment of a 13-year-old boy with behavioural dyscontrol, a finding that suggested a possible role for gabapentin in the treatment of other behavioural disorders.
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