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Initial dose: The starting dose is 300 mg three times a day. Dose Range: The dose may be increased, depending on the response and tolerance of the patient, using 300 or 400 mg capsules, or 600 or 800 mg tablets 3 times a day up to 1800 mg/ day. In clinical trials, the effective dosage range was 900 to 1800 mg/day, given 3 times a day Gabapentin (Neurontin, Gralise, Horizant) is a medicine used to treat partial seizures, nerve pain from shingles and restless leg syndrome. It works on the chemical messengers in your brain and nerves. Gabapentin is from a group of medicines called anticonvulsants. U.S.-based MDs, DOs, NPs and PAs in full-time patient practice can register for free access to the Prescribers’ Digital Reference on PDR.net. PDR.net is to be used only as a reference aid, it is not intended to be a substitute for the exercise of professional judgement. What side effects can this medication cause? All medicines can cause side effects, which may range from mild to severe. The most common side effects of gabapentin are: • Drowsiness Taking the first dose at night is preferred. • Dizziness • Dry mouth use sugarfree gum/lozenges or Biotene® mouth rinses to help reduce this Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. How should I store gabapentin tablets? • Keep gabapentin tablets and all medicines out of the reach of children. General information about the safe and effective use of gabapentin tablets The starting dose range is 10 mg/kg/day to 15 mg/kg/day, given in three divided doses, and the recommended maintenance dose reached by upward titration over a period of Hemodialysis (CrCl ; 15 mL/min): Administer supplemental dose (range 125-350 mg) posthemodialysis, after each 4 hr dialysis interval; further dose reduction should be in proportion to CrCl (eg, Trusted by generations of healthcare providers, PDR.net supports prescribing decisions and patient adherence to improve health. PDR delivers critical drug information and resources trusted and relied on by prescribers for generations. gabapentin affects you. Gabapentin can slow your thinking and motor skills. What are the possible side effects of gabapentin? Gabapentin may cause serious side effects including: See “What is the most important information I should know about gabapentin?” • problems driving while using gabapentin. taken in dose selection, and dose should be adjusted based on creatinine clearance values in these patients. 2.5 Administration Information Administer gabapentin orally with or without food. Gabapentin capsules should be swallowed whole with water. If the gabapentin dose is reduced, discontinued, or substituted with an alternative etic neuralgia have received gabapentin tablets at doses up to 1,800 mg daily during placebo-controlled clinical studies. In clinical trials in patients with postherpetic neur. Therapy: If TEVA-GABAPENTIN dose is reduced, discontinued or substituted with an alternate anticonvulsant or an alternate anticonvulsant is added to gabapentin therapy, this should be done gradually over a minimum of 1 week (a longer period may be needed at the discretion of Continue on this dose as advised Side Effects As well as benefits, all medicines potentially have unwanted effects, called side-effects and Gabapentin is no different. Increasing the tablets over a period of time this helps to reduce side-effects and possibly even avoid them. Common Occasional Dizziness Dry mouth Tiredness Visual disturbance What are some other side effects of this drug? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Feeling dizzy, sleepy, tired, or weak. Diarrhea, upset stomach, or gabapentin, like Lyrica, does have abuse potential. This reinforces the importance of ensuring each patient taking gabapentin has an appropriate indication, dose and frequency to maximize benefit and avoid adverse events or misuse. Daily Dose of Gabapentin (mg/day) Daily Dose of Lyrica (mg/day) 0 – 300 50 301 – 450 75 451 – 600 100 Detailed Gabapentin dosage information for adults and children. Includes dosages for Restless Legs Syndrome, Epilepsy and Postherpetic Neuralgia; plus renal, liver and dialysis adjustments. There was a larger treatment effect in patients 75 years of age and older compared to younger patients who received the same dosage. Since gabapentin is almost exclusively eliminated by renal excretion, the larger treatment effect observed in patients ≥ 75 years may be a consequence of increased gabapentin exposure for a given dose that No dosage adjustment is necessary for elderly patients unless their renal function is compromised (see Table 2). 4.3 Contraindications Gabapentin is contraindicated in patients who have demonstrated hypersensitivity to gabapentin or the inactive ingredients in the capsules. 4.4 Special warnings and precautions for use . General Detailed dosage guidelines and administration information for Neurontin (gabapentin). Includes dose adjustments, warnings and precautions. Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. Gabapentin elimination rate constant, plasma clearance, and renal clearance are
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