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Gabapentin was originally approved to treat epilepsy in humans. However, gabapentin became more useful as a drug to control nerve pain. More recently, the inhibitory (reducing brain activity) effects of gabapentin have been useful to control anxiety in animals, especially when being transported. Rabbits were randomly assigned (www.randomizer.org) to receive 1 of 2 doses, 25 or 50 mg/kg, of gabapentin. For drug administration, non-fasted rabbits were manually restrained and received the gabapentin suspension orally via syringe. In this study, 5 intact female and 3 intact male New Zealand white rabbits aged 8 to 12 months were administered a single oral 25-mg/kg dose of gabapentin. This study was conducted from December 2020 to February 2021. This drug is particularly well received by cats due to its formulation as a honey syrup. Also, the drop formulation makes it very easy to gradually and accurately decrease the dose. Morphine (oral liquid) 0.2–0.5 mg/kg PO TID–QID. Best compounded into palatable flavoured syrup; however, cats usually strongly resent this medication. Gabapentin Gabapentin is an effective analgesic in other species, specifically for neuropathic and chronic pain. A dosage of gabapentin at 25 mg/kg SC did reach plasma concentrations that provide analgesia in humans. 10 To assess the effect of gabapentin on stress in rabbits, 5 female and 3 male New Zealand white rabbits, aged 8-12 months, weighing 3-4.5 kg, were administered a single dose (25 mg/kg) of oral compounded gabapentin. In some cases, rabbits become resistant to the effects of a drug that has been used for a while and it may be necessary to change to a different analgesic. Local Anesthetics Local anesthetics can be administered in the form of topical creams or drops or by injection into the skin. The dose is typically calculated based on the rabbit’s weight, and it’s essential to follow the vet’s prescribed dosage closely. A common dose is 25 mg/kg orally which has been shown to decrease reactivity with peak effect at around 2 hours. Gabapentin has been used as an anxiolytic in various species, but little information is available on its use in rabbits. To assess the effect of gabapentin on stress in rabbits, 5 female and 3 male New Zealand white rabbits, aged 8-12 months, weighing 3-4.5 kg, were administered a single dose (25 mg/kg) of oral compounded gabapentin. Rabbits that received 25 mg/kg of gabapentin SC reached plasma concentrations that are analgesic in humans. 66 Rabbits that received gabapentin following a spinal cord ischemic injury had lower tissue injury markers compared with control rabbits indicating it may have neuroprotective properties. 67, 68 Clinical dosing is currently extrapolated Doses have increased in recent years following more observational and laboratory studies, and are typically: 0.6mg/kg q12-24h by all routes with a maximum dose of 1.5mg/kg/day suggested. What is the recommended dosage of gabapentin for rabbits? A common dosage is 25 mg/kg orally . However, the exact dosage should be determined by your veterinarian, as it may vary based on the individual rabbit’s condition and needs. Gabapentin, a chemical analogue of γ-aminobutyric acid that acts through inhibition of calcium-voltage-gated subunit receptors, is used to treat seizures, neuropathic pain and anxiety. Currently, dosage recommendations for rabbits are extrapolated from other species. Drug Dosage Calculator For Rabbits. A tool that automatically computes the mean recommended dose and volume of your rabbit's medicine. (Note for mobile user: Swipe left at the table to view the mean recommended dose and volume. It is very unlikely for the condition to improve once your rabbit is showing signs of distress, and It’s vital to get the pain under control as quickly as possible. Although no pain-killing medications are licensed for rabbits, a rabbit-savvy vet will have a good experience of what drugs are effective and safe when used at the proper dosage. Gabapentin (Neurontin, Pfizer) Dosages for rabbits have not been established: Indicated for adjunctive treatment of chronic or neurogenic pain in dogs and cats at 3 mg/kg PO q24h and for ancillary therapy of refractory seizures in dogs and cats at 10-30 mg/kg PO q8h 142 : 25 mg/kg SC 95: Dose used to approximate plasma concentrations in humans Gabapentin is not used for minor pain or arthritis even if its use in persons suffering from osteoarthritis and fibromyalgia has been studied. Some US veterinarians do, nowadays, suggest the off-label administration of gabapentin to control pain in rabbits suffering from arthritis, without studies of In rabbits, gabapentin typically begins to take effect within 1 to 2 hours after oral administration, with peak effects often observed around 2 hours. This relatively rapid onset makes it a valuable option for situations where anxiety relief is needed promptly. Radulovic L L, Turck D, Von Hodenberg A et al (1995) Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys. Drug Metab Dispos 23 (4), 441-448 PubMed. Petrere J A & Anderson J A (1994) Developmental toxicity studies in mice, rats and rabbits with the anticonvulsant gabapentin. Fundam Applied Toxicol 23 (4), 585-589 PubMed. Rabbits receiving the low dose of gabapentin seem a bit more relaxed, with no obvious adverse effects. Because of the findings of the study, clients of the Veterinary Teaching Hospital who own rabbits, and even guinea pigs, have been offered the option to use gabapentin prior to a stressful event.
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