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Gabapentin *Additional information is available within the SPC or upon request to the company Scan the QR code or enter an email to access and share this medicine: The starting dose should range from 10 to 15 mg/kg/day and the effective dose is reached by upward titration over a period of approximately three days. The effective dose of gabapentin in children aged 6 years and older is 25 to 35 mg/kg/day. Dosages up to 50 mg/kg/day have been well tolerated in a long term clinical study. Patients 12 years of age and above: starting dose of Gabapentin is 300 mg three times a day. The recommended maintainence dose of Gabapentin is 300 mg to 600 mg three times a day. Dosages up to 2400 mg/day have been well tolerated in long term clinical studies. Gabapentin is eliminated from the systemic circulation by renal excretion as unchanged drug. Gabapentin is not appreciably metabolized in humans. Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. Gabapentin elimination rate constant, plasma clearance, and renal clearance are directly dose of gabapentin in children aged 6 years and older is 25 to 35 mg/kg/day. Dosages up to 50 mg/kg/day have been well tolerated in a long-term clinical study. The total daily dose should be divided in three single doses, the maximum time interval between doses should not exceed 12 hours. 400 mg oral doses of gabapentin. The mean gabapentin half-life ranged from about 6.5 hours (patients with creatinine clearance >60 mL/min) to 52 hours (creatinine clearance <30 mL/min) and Gabapentin did not increase the incidence of malformations, compared to controls, in the offspring of mice, rats, or rabbits at doses up to 50, 30 and 25 times respectively, the daily human dose of 3600 mg, (four, five or eight times, respectively, the human daily dose on a mg/m 2 basis). Child 6–11 years 10 mg/kg once daily (max. per dose 300 mg) on day 1, then 10 mg/kg twice daily (max. per dose 300 mg) on day 2, then 10 mg/kg 3 times a day (max. per dose 300 mg) on day 3; usual dose 25–35 mg/kg daily in 3 divided doses, some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate, daily dose maximum to be given in 3 divided The dose of gabapentin should be adjusted in patients with reduced renal function, according to Table 2. Patients with reduced renal function must initiate gabapentin at a daily dose of 300 mg. Gabapentin should be titrated following the schedule outlined in Table 1. Thereafter, based on individual patient response and tolerability, the dose can be further increased in 300 mg/day (6ml) increments every 2-3 days up to a maximum dose of 3600 mg/day (72ml). Slower titration of gabapentin dosage may be appropriate for individual patients. If gabapentin is not effective or not tolerated, discontinue treatment gradually over a minimum of 1 week. Adjust the dose for people with renal impairment (see Table 2). Consult the manufacturer's Summary of Product Characteristics if the person is undergoing haemodialysis. Table 2. The starting dose should range from 10 to 15 mg/kg/day and the effective dose is reached by upward titration over a period of approximately three days. The effective dose of gabapentin in children aged 6 years and older is 25 to 35 mg/kg/day. Dosages up to 50 mg/kg/day have been well tolerated in a long-term clinical study. Gabapentin did not increase the incidence of malformations, compared to controls, in the offspring of mice, rats, or rabbits at doses up to 50, 30 and 25 times respectively, the daily human dose of 3600 mg, (four, five or eight times, respectively, the human daily dose on a mg/m 2 basis). The dose must be reduced in renal impairment based upon individualised creatinine clearance. Information about dosing of gabapentin in renal impairment and/or those undergoing haemodialysis can be found in the Summary of Product Characteristics (SPC) for the particular product, available from the electronic Medicines Compendium (eMC) website. Detailed Gabapentin dosage information for adults and children. Includes dosages for Restless Legs Syndrome, Epilepsy and Postherpetic Neuralgia; plus renal, liver and dialysis adjustments. Renal impairment: dose reductions are recommended for both pregabalin (CrCl<60ml/min) and gabapentin (CrCl< 80ml/min). If appropriate to switch, please also refer to www.medicines.org.uk for further information on recommended dose of gabapentin. 5. Discontinuing The summary of product characteristics for gabapentin and pregabalin indicate that both 1. WHAT GABAPENTIN CAPSULES ARE AND WHAT THEY ARE USED FOR Gabapentin capsules, hard (called Gabapentin capsules in the rest of this lea˜et) belong to a group of medicines used to treat epilepsy and peripheral neuropathic pain (long lasting pain caused by damage to the nerves). Gabapentin capsules are used to treat: The starting dose range is 10 mg/kg/day to 15 mg/kg/day, given in three divided doses, and the recommended maintenance dose reached by upward titration over a period of Gabapentin did not increase the incidence of malformations, compared to controls, in the offspring of mice, rats, or rabbits at doses up to 50, 30 and 25 times respectively, the daily human dose of 3600 mg, (four, five or eight times, respectively, the human daily dose on a mg/m 2 basis). Slower titration of gabapentin dosage may be appropriate for individual patients. The minimum time to reach a dose of 1800 mg/day is one week, to reach 2400 mg/day is a total of 2 weeks, and to reach 3600 mg/day is a total of 3 weeks. Dosages up to 4800 mg/day have been well tolerated in long-term open-label clinical studies.
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