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Gabapentin is eliminated from the systemic circulation by renal excretion as unchanged drug. Gabapentin is not appreciably metabolized in humans. Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. Gabapentin elimination rate constant, plasma clearance, and renal clearance are directly Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis. Gabapentin is an anticonvulsant. General drug facts If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else’s drugs. Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid that was first approved for use in the United States in 1993. 16 It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures 14,5 - today it is also widely used to treat neuropathic pain. 8,10 Gabapentin has During the controlled epilepsy trials in patients older than 12 years of age receiving doses of gabapentin up to 1800 mg daily, somnolence, dizziness, and ataxia were reported at a greater rate in patients receiving gabapentin compared to placebo: i.e., 19% in drug versus 9% in placebo for somnolence, 17% in drug versus 7% in placebo for Gabapentin is commonly used to treat and prevent seizures in people with epilepsy or to treat nerve pain (postherpetic neuralgia) that can occur after a viral infection called shingles. Generic name: gabapentin [ GA-ba-PEN-tin ] Drug class: Gamma-aminobutyric acid analogs. Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 21, 2025. Uses; Warnings; Before taking; Dosage; Side effects; Interactions; FAQ; What is Neurontin? Neurontin is an anti-epileptic drug, also called an anticonvulsant. It affects chemicals 7 DRUG INTERACTIONS . 7.1 Other Antiepileptic Drugs 7.2 Opioids . 7.3 Maalox ® (aluminum hydroxide, magn esium hydroxide) 7.4 Drug/Laboratory Test Interactions . 8 USE IN SPECIFIC POPULATIONS . 8.1 Pregnancy . 8.2 Lactation 8.4 Pediatric Use . 8.5 Geriatric Use 8.6 Renal Impairment . 9 DRUG ABUSE AND DEPENDENCE . 9.1 Controlled Substance . 9.2 3/27/2021 Gabapentin: Patient drug information - UpToDate Gabapentin is an anticonvulsive medication that received approval from the US Food and Drug Administration (FDA) in 1993 and has been available in generic form in the USA since 2004. Gabapentin was originally used as a muscle relaxant and an anti-spasmodic. However, it was later discovered that gabapentin has the potential of an anticonvulsive medication and can be used as an adjunct to more Gabapentin is an anticonvulsant medication approved for seizures, nerve pain, and restless legs syndrome. It can also be prescribed off-label for other conditions, but it may have serious side effects and risks. Like other antiepileptic drugs, gabapentin may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any of these symptoms, especially if they are Following concerns about abuse, gabapentin has been reclassified as a Class C controlled substance and is now a Schedule 3 drug, but is exempt from safe custody requirements. Healthcare professionals should evaluate patients carefully for a history of drug abuse before prescribing gabapentin, and observe patients for signs of abuse and dependence. Gabapentin (Neurontin, Gralise, Horizant) is a medicine used to treat partial seizures, nerve pain from shingles and restless leg syndrome. It works on the chemical messengers in your brain and nerves. Gabapentin is from a group of medicines called anticonvulsants. Gabapentin is approved to prevent and control partial seizures, relieve postherpetic neuralgia after shingles and moderate-to-severe restless legs syndrome. Learn what side effects to watch for, drugs to avoid while taking gabapentin, how to take gabapentin and other important questions and answers. Gabapentin is in a class of medications called anticonvulsants. Gabapentin treats seizures by decreasing abnormal excitement in the brain. Gabapentin relieves the pain of PHN by changing the way the body senses pain. It is not known exactly how gabapentin works to treat restless legs syndrome. Gabapentin is a medication that treats nerve pain by calming overactive nerves in your body. It may also prevent and control seizures in people with epilepsy. You can take this medication by mouth with a glass of water. Gabapentin is an anticonvulsant with pain-relieving effects that may be used to treat partial-onset seizures or relieve nerve pain. Highlights of Prescribing Information. T hese highlights do not include all the information needed to use gabapentin capsules safely and. effectively. See full prescribing information for gabapentin capsules. GABAPENTIN capsules, USP for oral use. Initial U.S. Approval: 1993 What Is Gabapentin and How Does It Work? Gabapentin is a prescription drug most commonly prescribed to relieve nerve pain following shingles in adults, treating the pain of post herpetic neuralgia. Gabapentin belongs to a class of drugs known as anti- seizure drugs.
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