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It is important to inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are taking to avoid potential interactions. Drug Interactions Medications that may interact with gabapentin. Gabapentin can interact with several medications, leading to different effects. Are there any serious interactions with gabapentin and other medications? Serious breathing problems can happen if you take gabapentin with drugs that cause severe sleepiness or decreased awareness. Some examples include narcotic opioids, anti-anxiety medicines, antidepressants, and antihistamines. Understand Drug Interactions: Gabapentin interacts with opioids, antacids, and more. Opioid Risks: Combining gabapentin with opioids can lead to increased sedation. Antacid Timing Matters: Take antacids at least two hours apart from gabapentin. Drug Interactions between gabapentin and Heartburn Antacid Extra Strength. This report displays the potential drug interactions for the following 2 drugs: gabapentin; Heartburn Antacid Extra Strength (alginic acid/aluminum hydroxide/magnesium carbonate) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Seizure medications: Some anticonvulsants like phenobarbital and primidone may have interactions with gabapentin. Morphine and other opioids: Taking opioids with gabapentin can increase the risk of respiratory depression, a serious and potentially fatal side effect. Phenytoin: This anti-seizure medication can have complex interactions with Aluminum hydroxide and magnesium hydroxide antacids may decrease the bioavailability of gabapentin by as much as 20%. A dose of aluminum or magnesium hydroxide should precede a dose of gabapentin by at least two hours. Specific Drugs: Gabapentin can interact with other prescription medications such as losartan, ethacrynic acid, caffeine, phenytoin, mefloquine, magnesium oxide, cimetidine, naproxen, sevelamer, and morphine. These interactions can lead to altered drug levels or an increased risk of side effects. Some common drug interactions with gabapentin include: NSAIDs (nonsteroidal anti-inflammatory drugs): Medications such as ibuprofen or naproxen may interact with gabapentin, increasing the risk of side effects such as drowsiness, dizziness, or stomach ulcers. Specific Medications: Gabapentin can also interact with specific medications including losartan (an antihypertensive), ethacrynic acid (a diuretic), phenytoin (an anticonvulsant), mefloquine (an antimalarial), magnesium oxide (an antacid), cimetidine (an antacid), naproxen (an NSAID), and sevelamer (a phosphate binder). These interactions can Drug Interactions between gabapentin and Tums Regular Strength. This report displays the potential drug interactions for the following 2 drugs: gabapentin; Tums Regular Strength (calcium carbonate) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Those taking gabapentin should therefore always disclose to their doctors any medical conditions, other medications (prescription or over the counter), supplements, herbal products, illicit drugs, tobacco products, alcoholic beverages, and dietary choices. This way, their doctors can better evaluate the risk of interactions. Drug Interactions An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Common medications that may interact with gabapentin include: antacids, such as those containing aluminum and magnesium Antacids can reduce the amount of gabapentin that the body takes in so it does not work as well. To stop this happening, if you need to take an antacid, take it at least 2 hours before or after your dose of gabapentin. Information for our drug interactions is compiled from several drug compendia, including: Gold Standard Drug Database; Micromedex; Lexicomp; DrugBank; The prescribing information for each drug, as published on DailyMED, is also used. Individual drug-drug interaction detail pages contain references specific to that interaction. Gabapentin is commonly prescribed with other medications. It is safe to take gabapentin with other medications, but understanding the possible drug interactions can help you live a healthier life. Gabapentin, also known by its brand name Neurontin, is a medication that has been used in the United States since the early 1990s. The drug helps Generally speaking, you need to avoid combining Gabapentin with substances that increase drowsiness, such as opioids, benzodiazepines, and alcohol. Also avoid some antacids, because they reduce the absorption of gabapentin into the bloodstream. Antacids, particularly those containing magnesium and aluminum, can interfere with the metabolism of the drug possibly leading to a reduction in its desired pharmacologic effects. In order to prevent this drug interaction, patients are advised to delay administration of gabapentin to at least 2 hours after taking the antacid. In general, some studies have shown that gabapentin is an antiepileptic drug with a low profile of interaction with other drugs. 68, 69 Specifically, a general review stated that gabapentin lacks interactions with hepatic enzymes, plasma proteins and other drugs; these factors make gabapentin suitable for elderly patients suffering from hepatic
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