Not Likely: It is unlikely that Neurontin (Gabapentin) will trigger a false positive urine test for drugs. However, if you are taking other medications then these medication may alone or in combination with Neurontin trigger a positive urine screen. I think Gabapentin can show for a false positive for benzos, but like 95% of the time, this isn't the case. They act on the same Neurotransmitter (GABA) but have different mechanisms of action. Gabapentin acts on increasing GABA indirectly via voltage-gated calcium channels, and Benzos bind to the Benzodiazepine receptors/GABA A receptors A false-positive test result means that your drug test shows the presence of a medication or substance that you aren't actually taking. For example, a methamphetamine test comes back positive for methamphetamines, even though you haven't taken any. Drug testing, commonly used in health care, workplace, and criminal settings, has become widespread during the past decade. Urine drug screens have been the most common method for analysis because of ease of sampling. The simplicity of use and access to rapid results have increased demand for and use of immunoassays; however, these assays are not perfect. False-positive results of immunoassays The issue is not that gabapentin rarely results in a false positive as I was told the same nonsense. The issue is the test performed, the instrumentality used and the laboratory that performed the drug test. What laboratory performed your test for gabapentin and if you know, what was the test code and procedure/instrumentality used? However, since most false positives occur as a result of an antibody binding to a drug that has a similar structure, it makes sense that the risk of a false-positive gabapentin test is highest with other anti-epileptic drugs, or those similar to it. Certain medications can trigger a false positive on a urine drug test. Discover which medications can do this and how to respond to a false-positive result. I take a drug test every two weeks and my counselor told me it would be fine and would not cause a problem at all but I would say it may depend also on the type of drug test, some are so much more easier to pick up stuff this is a test that I take that is done in a lab and it is one like they use in dr. office so I think quest does this test. Can gabapentin cause false positive on drug test? No, gabapentin does not cause false positives on drug tests. It is not an illicit substance and it will not show up as a false positive for any other drugs. At the time of the study, neither fentanyl nor gabapentin was included in the immunoassay-based urine drug screen used by the hospital. It is possible that individuals presenting to the hospital may have been drug seeking and discharged with prescriptions for gabapentin based on a “clean” drug screen. Purpose: The implications of potential false-positive urine drug screen (UDS) results for patients receiving commonly prescribed medications were evaluated. Summary: A comprehensive literature review was conducted to identify false-positive UDSs associated with all clinic formulary medications, as well as common nonprescription medications. One study found morphine levels high enough to result in positive EIA testing after ingestion of 1 poppy seed muffin or 2 poppy seed bagels. 8 This type of false-positive result is much less common in testing outside of clinical situations (eg, the workplace), wherein thresholds for a positive opiate screening are higher. 9 A careful history It's very uncommon (and unlikely) to get a false positive test result for gabapentin. Gabapentin is not a controlled or illicit substance and is not included on standard urinalysis drug tests. I looked in multiple research articles on prescription medications that can cause false positives on drug screens, and gabapentin/Neurontin did not show up in the lists of any of these professional research studies. A variety of medications can cause a false positive result on a drug screen, but the occurrence of a false-positive result for cocaine is very rare. False positives are far more common for other medications such as amphetamines and opioids. Cocaine False Positives screening and confirmatory drug tests. Immunoassays are qualitative tests used for initial screening of urine samples. They can give false-positive and false-negative results, so all results are Neurontin (gabapentin) is not a medication that is typically associated with 'false positives' on most drug tests, including Suboxone (buprenorphine). It is not a reported/listed drug in most literature searches of agents that are most likely to cause 'false positives'. However, antibodies may detect drug metabolites with similar structure and characteristcis, leading to false-positive results. For this reason, immunoassay testing should be considered preliminary and presumptive. Most studies suggest that gabapentin is highly unlikely to cause a 'false-positive' for any of the drugs being looked for on a standard 5-panel test due to its difference in structure and molecular composition. Nevertheless, there are some studies that report that it may interfere with certain tests for amphetamines. Gabapentin and pregabalin have a minimal risk of causing false-positives and are other options that could be used. Trazodone is an antidepressant frequently used as a sleep aid. Minimizing its use and instead using mirtazapine or sedative-hypnotics when appropriate would be another consideration. 1-4.
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