Gabapentin may be used during pregnancy only when the benefits outweigh the potential risks. In animal studies, gabapentin has been shown to increase the risk for fetal malformation, particularly delayed bone formation. An expert panel has deemed this drug is an acceptable choice for refractory restless leg syndrome during lactation. Until more data becomes available, the developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for this drug and any potential adverse effects on the breastfed infant from this An expert consensus guideline indicates that gabapentin is an acceptable choice for refractory restless leg syndrome during lactation.[2] Limited information indicates that maternal doses of gabapentin up to 2.1 grams daily produce relatively low levels in infant serum. Gabapentinand breastfeeding. gabapentin is considered compatible with breastfeeding, but should be used with caution and infant monitoring (1) published evidence for the use of gabapentin during breastfeeding is very limited. Data is from 10 mothers using gabapentin doses up to 2.1g daily pregabalin or gabapentin during lactation, the de-velopmental effects of breastfeeding and the clinical needs of the mother should be considered. The po-tential side effects of the drug on the infant and the maternal condition should be evaluated. Conflict-of-interest issues regarding the authorship or article: None declared. DrLact safety Score for Gabapentin is 1 out of 8 which is considered Safe as per our analyses. A safety Score of 1 indicates that usage of Gabapentin is mostly safe during lactation for breastfed baby. Our study of different scientific research also indicates that Gabapentin does not cause any serious side effects in breastfeeding mothers. A single oral dose of either 300 mg or 600 mg given to the mother before cesarean section appeared to have no effect on breastfeeding initiation.[1] An expert consensus guideline indicates that gabapentin is an acceptable choice for refractory restless leg syndrome during lactation.[2] AEDs with a less documented safety profile during lactation (moderately safe). Gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin and vigabatrin may be used during lactation, but their lowest dose should be prescribed. The nursing infant should be carefully monitored and, if required, the infant drug plasma-level tested. A single oral dose of either 300 mg or 600 mg given to the mother before cesarean section appeared to have no effect on breastfeeding initiation.[1] An expert consensus guideline indicates that gabapentin is an acceptable choice for refractory restless leg syndrome during lactation.[2] Breastfeeding while taking gabapentin: Gabapentin enters breastmilk in low levels. Blood tests on breastfed infants found low levels or levels too low to be detected. There are reports of infants exposed to gabapentin through breastmilk; no side effects were noted. Gabapentin is considered compatible with breastfeeding, but should be used with caution and infant monitoring. Published evidence for the use of gabapentin during breastfeeding is very limited. Data is from 10 mothers using gabapentin doses up to 2.1g daily. Gabapentinoids include gabapentin (Neurontin) and pregabalin (Lyrica). These medicines also may be used to treat ongoing pain or pain after procedures. Gabapentinoids are considered safe to use while breastfeeding. Ohman I, Vitols S, Tomson T. Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: Does a fetal accumulation occur during pregnancy? Epilepsia. 2005;46:1621–4. Ohman I, Tomson T. Gabapentin kinetics during delivery, in the neonatal period, and during lactation. Epilepsia 2009;50 (Suppl. 10):108. Abstract. Breastfeeding while taking gabapentin: Gabapentin enters breastmilk in low levels. Blood tests on breastfed infants found low levels or levels too low to be detected. • Kristensen JH, Ilett KF, Hackett LP, Kohan R, Gabapentin and breastfeeding: a case report, J Hum Lact, 2006;22:426–8. • Öhman I, Vitols S, Tomson T, Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy? Epilepsia, 2005;46:1621–4. If your doctor or health visitor says your baby is healthy, you can take gabapentin while breastfeeding. It's important to keep taking gabapentin to keep you well. Gabapentin passes into breast milk in small amounts. This article summarizes the current literature regarding gabapentin use during pregnancy and related prenatal and neonatal exposure outcomes with special consideration for interactions between gabapentin and opioid use. Consequently, 19 drugs can be used during lactation, and 28 have insufficient data to evaluate. Among the drug subclasses, selective serotonin reuptake inhibitors were most thoroughly studied Another prospective study in Norway followed infants of mothers who took antiepileptic drugs during pregnancy and lactation. These infants were compared with control groups of infants of mothers with untreated epilepsy and infants with fathers who took antiepileptics. 3 Infants were assessed at 6, 18, and 36 months of age. This article summarizes the current literature regarding gabapentin use during pregnancy and related prenatal and neonatal exposure outcomes with special consideration for interactions between gabapentin and opioid use.
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