gabapentin during pregnancy can gabapentin cause itchy rash

Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes. Due to mixed findings on its safety during pregnancy, gabapentin shouldn’t be taken during pregnancy without first discussing it with your doctor. Gabapentin (Neurontin) is an anti-seizure medication that’s also used for certain types of neuropathic pain. Gabapentin is an antiepileptic drug that may cause birth defects and harm the fetus or breastfed infant. Learn about the risks, benefits, and alternatives of using gabapentin during pregnancy and lactation. It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take gabapentin. Does taking gabapentin increase the chance of miscarriage? Learn about the reproductive safety of gabapentin, a medication used for various conditions, from a study and a review of the available data. The risk of major malformations is low, but there may be higher rates of preterm births and low birth weight. More research is required to define the pregnancy safety profile of gabapentin. Pregnant women and women of childbearing potential should be made aware of the lack of data for most pregnancy outcomes. Gabapentin should only be used during pregnancy where benefits of treatment are considered to outweigh any potential risks. Five studies reported significant findings with increased risks of overall congenital anomalies, specific anomalies (nervous system, eyes, oro-facial clefs, urinary and genital system), miscarriage, stillbirth and specific neurodevelopmental outcomes after exposure to pregabalin during pregnancy. We have data on 223 pregnancy outcomes exposed to gabapentin and 223 unexposed pregnancies. The rates of major malformations were similar in both groups (p = 0.845). There was a higher rate of preterm births (p = 0.019) and low birth weight <2,500 g (p = 0.033) in the gabapentin group. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. Gabapentin is a γ-aminobutyric acid analog formally indicated for the treatment of epilepsy and neuropathic pain that is gaining increased popularity. Gabapentin has been historically considered a safe medication, including during pregnancy and lactation, with low reported concerns for misuse and us Gabapentin (Neurontin®) is mainly used to treat epilepsy and nerve pain, and to prevent migraine. What are the benefits of taking gabapentin in pregnancy? Gabapentin prevents epileptic seizures, which can be dangerous to the woman and also lead to pregnancy complications. We examined the risk of major congenital malformations and cardiac defects associated with gabapentin exposure during the first trimester (T1), and the risk of preeclampsia (PE), preterm birth (PTB), small for gestational age (SGA), and neonatal intensive care unit admission (NICUa) associated with gabapentin exposure early, late, or both early Gabapentin and pregnancy. Gabapentin is not generally recommended in pregnancy as there is not enough information about whether it's safe for your baby. However, from the small amount of information that is available, there's no clear evidence that it's harmful. It should only be taken if the benefits of the medicine outweigh the risks. Learn about gabapentin use in pregnancy and breastfeeding, based on published literature and expert opinions. Find out the potential risks, benefits, and alternatives of this medication for seizures, nerve pain, and restless legs syndrome. Selected References: Blotiere PO, et al. 2020. Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. BMJ Open 10(6). Brannon GE, Rolland PD. Anorgasmia in a patient with bipolar disorder type 1 treated with gabapentin. J Clin Psychopharmacol. 2000;20(3):379 Among these, 4,642 (0.26%) were exposed to gabapentin during T1, 3,745 (0.21%) were exposed to gabapentin early in pregnancy only (during the first 140 days), 556 (0.03%) were exposed late in pregnancy but not early, and 1,275 (0.07%) were exposed in both early and late pregnancy . In this study with over 4000 infants exposed to gabapentin, the information is reassuring. While we cannot rule out the possibility of a small increase in risk of cardiovascular malformations in gabapentin-exposed infants, gabapentin does not appear to be a major teratogen. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as gabapentin, during pregnancy. Encourage women who are taking gabapentin during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling the toll free number 1-888-233-2334 or The study supports the reproductive safety of gabapentin during pregnancy.

gabapentin during pregnancy can gabapentin cause itchy rash
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