A study from the European Gabapentin Registry included prospective and retrospective data with a total of 51 outcomes and 44 live births of women with epilepsy and other disorders exposed to gabapentin during pregnancy. The study supports the reproductive safety of gabapentin during pregnancy. While there is currently no clear evidence that gabapentin is harmful during pregnancy, the available data suggests a possible correlation between its use and preterm births, which can result in lower birth weights. It has not been known to cause any side effects in breastfed babies. If your baby is not feeding as well as usual, seems unusually sleepy, has a stomach upset, or if you have any other concerns about your baby, talk to your doctor, pharmacist, health visitor or midwife. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as gabapentin, during pregnancy. Encourage women who are taking gabapentin during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling the toll-free number 1-888-233-2334 or Five studies reported significant findings with increased risks of overall congenital anomalies, specific anomalies (nervous system, eyes, oro-facial clefs, urinary and genital system), miscarriage, stillbirth and specific neurodevelopmental outcomes after exposure to pregabalin during pregnancy. Gabapentin may be used during pregnancy only when the benefits outweigh the potential risks. In animal studies, gabapentin has been shown to increase the risk for fetal malformation, particularly delayed bone formation. Some of the most commonly affected parts include the skull, backbone and the extremities. Does taking gabapentin in pregnancy increase the chance of other pregnancy-related problems? Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. Results from this large cohort study suggest that gabapentin exposure during early pregnancy does not appear to be associated with teratogenic effects, although a moderately higher risk of cardiac malformations—in particular, conotruncal defects—cannot be excluded. Dangerous side effects could occur. Gabapentin side effects. Get emergency medical help if you have signs of an allergic reaction to gabapentin: hives, difficult breathing, swelling of your face, lips, tongue, or throat. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. However, the withdrawal symptoms may be more of a problem if you took opioids with gabapentin during your pregnancy. This combination has been shown to produce more unusual side effects in newborns, and it is not known how these effects will affect the child as they grow. Side Effects Common side effects of gabapentin. Gabapentin can cause several common side effects, including dizziness, drowsiness, and fatigue. Other commonly reported side effects include headache, nausea, and blurred vision. These side effects are usually mild and tend to improve over time as the body adjusts to the medication. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as gabapentin, during pregnancy. Encourage women who are taking gabapentin during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling the toll free number 1-888-233-2334 or The most common side effects that were reported in studies of gabapentin are drowsiness (somnolence), dizziness, problems with movement and balance (ataxia), fatigue, and rapid and uncontrolled eye movement (nystagmus) in patients with epilepsy >12 years of age and viral infection, fever, nausea and/or vomiting, somnolence, and hostility in We examined the risk of major congenital malformations and cardiac defects associated with gabapentin exposure during the first trimester (T1), and the risk of preeclampsia (PE), preterm birth (PTB), small for gestational age (SGA), and neonatal intensive care unit admission (NICUa) associated with gabapentin exposure early, late, or both early Gabapentin can cause side effects‚ such as dizziness‚ drowsiness‚ and nausea. Pregnant women⁚ Gabapentin should be used during pregnancy only if the Overall, 1,753,865 pregnancies met the inclusion criteria. Among these, 4,642 (0.26%) were exposed to gabapentin during T1, 3,745 (0.21%) were exposed to gabapentin early in pregnancy only (during the first 140 days), 556 (0.03%) were exposed late in pregnancy but not early, and 1,275 (0.07%) were exposed in both early and late pregnancy . Advice and warnings for the use of Gabapentin during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out
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