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Six horses with chronic lameness referable to musculoskeletal pathology were randomly assigned to one of three treatments: 5 and. 10 mg/kg body weight of gabapentin, and placebo administered PO three times daily for 14 days. All horses received each treatment separated by a 2-week interval. “Gabapentin works by quieting excitable nerves and allowing other pain medications to be more effective,” says Bidwell. et al. Pharmacokinetics and bioequivalence of 2 meloxicam oral Equine Gabapentin Dose is a powerful medication that effectively manages chronic pain, neuropathic pain, and seizures in horses. It provides fast and long-lasting relief, allowing your horse to regain its vitality and quality of life. Our results suggest that horses tolerate gabapentin up to 120 mg/kg PO q 12 h for 14 days. The analgesic effect of the dosage regimens evaluated in our study warrants further research. Following baseline measurement of lameness, horses were administered each of four treatments orally in grain: treatment G, gabapentin (20 mg kg –1) twice daily for 13 doses; treatment F, firocoxib (171 mg once, then 57 mg once daily for six doses); treatment GF, gabapentin and firocoxib at previously stated doses and frequencies; or treatment C, grain only as a control. Our results suggest that horses tolerate gabapentin up to 120 mg/kg PO q 12 h for 14 days. The analgesic effect of the dosage regimens evaluated in our study warrants further research. Limited scientific information exists regarding the effective and safe dosing of gabapentin in horses. The information on the likely effective dose of gabapentin stated by Gold et al. (2020) and Gold et al. (2022) is not included in the table of the recommended doses in equine patients, which has since been published [89,90]. All horses tolerated the PO administration of gabapentin, and no evidence of side effect (e.g. somnolence, depression, sedation, or ataxia) of the drug at either dose (5 or 10 mg/kg bwt) was observed. Gabapentin. Gabapentin is an anti-epileptic drug that has been used to treat neuropathic pain and prevent windup. It’s mechanism of action is unclear but is thought to involve inhibition of neurotransmitter release. It has been shown to be absorbed in horses when given iv but has poor oral bioavailability (16%). 3. What is the Typical Dosage of Gabapentin for Horses? Dosage can vary, but generally, a range of 10-20 mg/kg is considered safe. Some studies have indicated that horses can tolerate doses up to 120mg/kg every 12 hours for 14 days without showing serious adverse effects. The precise dose and frequency should be determined by a veterinarian. Methods: Following baseline measurement of lameness, horses were administered each of four treatments orally in grain: treatment G, gabapentin (20 mg kg -1) twice daily for 13 doses; treatment F, firocoxib (171 mg once, then 57 mg once daily for six doses); treatment GF, gabapentin and firocoxib at previously stated doses and frequencies; or tre Davis et al [9] found that gabapentin administered at a dose of 2.5 mg/kg bwt PO every 8 hours to a pregnant draft horse was effective in the treatment of femoral neuropathy after colic surgery. Contrary to that suggested by Matthews and Dyson [26] of a slow onset of effective pain relief, the mare appeared to be more comfortable and less In the study, gabapentin was administered at a dosage of 20 mg/kg, which is considered safe in horses. 3 At this dosage, gabapentin did not improve any measure of lameness in horses with chronic musculoskeletal pain in the thoracic limbs. Dosage and Tolerance. Horses can tolerate high doses of gabapentin. Studies suggest that horses can tolerate up to 120 mg/kg PO every 12 hours for 14 days. However, it’s crucial to follow the vet’s prescribed dosage instructions. Although horses generally tolerate gabapentin well, each individual may react differently. orally administered gabapentin in horses has been described in several clinical reports (Davis et al. 2007; Dutton et al. 2009; Readfordetal.2013).However,Caldwelletal.(2015)reported no subjective improvement in lameness in horses administered gabapentin at oral doses of 5 and 10 mg kge1 three times daily for 14 days. Following baseline measurement of lameness, horses were administered each of four treatments orally in grain: treatment G, gabapentin (20 mg kg –1) twice daily for 13 doses; treatment F, firocoxib (171 mg once, then 57 mg once daily for six doses); treatment GF, gabapentin and firocoxib at previously stated doses and frequencies; or treatment C, grain only as a control. Horses tolerated both i.v. and p.o. gabapentin doses well. There were no significant differences in t1=2c and t1=2e. Oral administration yielded much lower plasma concentrations because of low bioavailability. Gabapentin has been used extensively for the treatment of pain of nerve origin in horses, and, more recently, for the treatment of other painful conditions including laminitis. It has been used at a dose rate of 5mg/kg to 20mg/kg, although the author has only been convinced of clinical effect at the top end of that range. Gabapentin has a relatively low bioavailability, but no apparent adverse effects following oral administration in horses 75, 76. Further work is needed to assess the clinical effect of gabapentin more objectively in horses with clinical pain. “Gabapentin is very poorly bioavailable, and responses are extremely variable. Plus, finding the correct dose can take weeks to months,” Hector said. Nonetheless, Hector noted, “I think that gabapentin is always worth a try if cost and availability don’t preclude an owner from spending money on something else that has better data behind it.
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