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Although not officially approved for anxiety, gabapentin’s calming effects on the nervous system have made it a subject of interest in mental health. Pregabalin, a derivative of gabapentin, was approved for use in 2004, primarily for treating neuropathic pain and as an adjunct therapy for partial seizures. Gabapentin can help to relieve the pain of neuropathic pain. Anxiety⁚ Gabapentin is sometimes used to treat anxiety disorders‚ such as generalized anxiety disorder and social anxiety disorder. Gabapentin is not a cure for any of these conditions‚ but it can help to control the symptoms. In substance use disorders, GBP is effective for acute alcohol withdrawal syndrome (AWS) with mild to moderate severity; it reduces cravings, improves the rate of abstinence, and delays return to heavy drinking. Medically Reviewed Gabapentin for Anxiety, Depression, and Bipolar Disorder. The prescription drug is being used off-label to treat common mental illnesses and even alcohol use disorder. Gabapentin's potential anxiolytic (anxiety-reducing) effects are thought to stem from its ability to modulate the activity of neurotransmitters involved in mood regulation, such as GABA and glutamate. By influencing these neurotransmitter systems, gabapentin may help to reduce anxiety symptoms by promoting a sense of calm and relaxation. While gabapentin is not yet an FDA-approved treatment for alcoholism, a number of studies support the its use withdrawal and cravings: In a 12-day study detoxifying with either gabapentin or lorazepam (a benzodiazepine prescribed with the brand name Ativan), the former was less likely to drink – and had less craving, anxiety, and sedation. In one study, women with anxiety, who were previously treated for breast cancer, were given gabapentin 300 mg or 900 mg daily. Compared to placebo (a pill with no medication in it), both doses of gabapentin improved anxiety symptoms after 4 and 8 weeks. Gabapentin can reduce your desire to drink and can help you stop drinking. Gabapentin may also help improve symptoms of anxiety and difficulty sleeping that may occur when stopping alcohol use. How does gabapentin work? • Gabapentin works on your brain to reduce your desire to drink alcohol. Evidence also suggests gabapentin is more effective in reducing the symptoms of alcohol withdrawal and certain types of anxiety than conditions like bipolar disorder, panic Some research shows that gabapentin has promise as an alcohol withdrawal treatment, possibly in combination with other medications. Gabapentin can: Help stop the impulse to drink, Gabapentin is an off-label medication for alcohol use disorder, sold under the brand names Neurontin, Gralise, and Horizant, among others. The medication was originally developed to treat epilepsy and is now FDA-indicated for a variety of additional uses, including the treatment of conditions like postherpetic neuralgia and restless leg syndrome. Anti-anxiety medications work more quickly than gabapentin and are sometimes recommended to treat symptoms of short-term or acute anxiety disorders like panic disorder. Beta blockers are a type of medication typically used to treat high blood pressure or heart conditions and they can also be helpful for treating performance-related anxiety like Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use disorder. There is sufficient evidence to consider gabapentin as a third-line treatment for social anxiety disorder and severe panic disorder. Gabapentin can reduce your desire to drink and can help you stop drinking. Gabapentin may also help improve symptoms of anxiety and difficulty sleeping that may occur when stopping alcohol use. How does gabapentin work? • Gabapentin works on your brain to reduce your desire to drink alcohol. Evidence from single-site studies lend support to the safety and efficacy of gabapentin as a novel treatment for alcohol use disorder, with unique benefits for alcohol-related insomnia and negative affect, relative to available treatments. The anticonvulsant drug gabapentin is used off-label to treat alcohol-related withdrawal, cravings, anxiety, and insomnia. Although it is well tolerated and has demonstrated efficacy for mild alcohol withdrawal and early abstinence, there is concern about its potential for abuse.
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